Effect of rifaximin on small intestinal microbiota and bile acid metabolism in mice with fatty liver

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K20848
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0902:General internal medicine and related fields
• Research Institution: The University of Tokyo
• Principal Investigator: Ikeuchi Kazuhiko 東京大学, 医学部附属病院, 助教 (70963221)
• Project Period (FY): 2022-08-31 – 2024-03-31
• Keywords: 脂肪肝 / リファキシミン / 胆汁酸 / 小腸 / 細菌叢

Outline of Final Research Achievements

In mice fed a high-fat diet, there was an increase in Erysipelotrichaceae and a decrease in Turibacteraceae in the ileum. Erysipelotrichaceae positively correlated with LDL cholesterol and blood glucose levels, while Turibacteraceae negatively correlated with these parameters. These changes and correlations were most significant in the ileum. Rifaximin had little impact on the proportions of these bacteria.

Free Research Field

感染症

Academic Significance and Societal Importance of the Research Achievements

高脂肪食と小腸細菌叢の関連についての研究は少ない。ErysipelotrichaceaeやTuribacteraceaeは脂質代謝と関係があるとされる菌種と報告されているが、特に回腸で変化が大きく、LDLコレステロールや血糖値との相関が強く、小腸の中でも回腸細菌叢の重要性が示唆された。一方で、リファキシミンはこれらの菌種に期待されるような変化は示せず、これらの菌種の変化が主体である病態においては効果が乏しい可能性が示唆された。