2023 Fiscal Year Final Research Report
Development of a novel fetal brain function assessment method to overcome the neurological sequelae of fetuses with fetal growth restriction.
| Project/Area Number |
22K20854
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0902:General internal medicine and related fields
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Project Period (FY) |
2022-08-31 – 2024-03-31
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| Keywords | 胎児発育不全 / 拡散強調画像 |
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| Outline of Final Research Achievements |
Fetal growth restriction is a condition in which fetal growth in the uterus is delayed or arrested for some reason. There is a need to establish a new evaluation method for fetal brain function that can be performed in utero. Therefore, we conceived the idea of using nuclear magnetic resonance imaging (MRI) to evaluate fetal brain function.Diffusion-weighted MRI images can diagnose cerebral ischemia, and diffusion coefficient images, in which the apparent diffusion coefficient is calculated and visualized, can quantitatively evaluate cellular edema.In this study, a guinea pig model of fetal growth retardation was created, and diffusion-weighted images were taken in the FGR and Shum groups. However, although the fetal growth retardation model was successfully created, diffusion-weighted images could not be obtained clearly due to the inhomogeneous magnetic field caused by maternal intestinal gas.
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| Free Research Field |
胎児発育不全
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| Academic Significance and Societal Importance of the Research Achievements |
本研究では、拡散強調画像（DWI）を用いた新たな胎児の脳機能評価方法を確立し、最終的には胎児発育不全児の神経学的後遺症を克服することを目標とした。3T MRI装置ではT2WIは胎仔脳を鮮明に撮像できたが、DWIに関しては母獣の便塊や腸管ガスの影響により磁場が乱れてしまい解析可能な個体が非常に少なく、両群で有意差が得られなかった。昨年度4.7T MRI装置用のマウス腹部コイルが新たに購入され、12月にマウス胎児のADC測定が可能であることを確認した。現在、研究の動物種をマウスに変更して胎仔のADCを検証する実験を計画している。
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