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2023 Fiscal Year Final Research Report

Regulation of skeletal muscle differentiation and autophagy by IL-15 in sarcopenia.

Research Project

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Project/Area Number 22K20887
Research Category

Grant-in-Aid for Research Activity Start-up

Allocation TypeMulti-year Fund
Review Section 0902:General internal medicine and related fields
Research InstitutionOsaka University

Principal Investigator

Yoshida Shino  大阪大学, 大学院医学系研究科, 助教 (80962612)

Project Period (FY) 2022-08-31 – 2024-03-31
KeywordsIL-15
Outline of Final Research Achievements

The aim of this study was to prove the involvement of myokine IL-15 in regulating skeletal muscle cell differentiation and autophagy in the mechanism of sarcopenia development. IL-15TG mice showed increased skeletal muscle phosphorylated AMPK and enhanced autophagy, which improved factors related to skeletal muscle metabolism and muscle strength. IL-15KO mice showed decreased lower limb skeletal muscle mass during exercise, and the exercise effect by AMPK could not be confirmed, suggesting that IL-15 expression is required for the exercise effect in skeletal muscle. Decreased autophagy induction was also observed, indicating that IL-15 gene deficiency induces decreased autophagy induction.

Free Research Field

老年医学

Academic Significance and Societal Importance of the Research Achievements

加齢性筋肉減少症(サルコペニア)は、高齢者の予後を大きく左右するため、その発症予測、重症度、治療のためのマーカーや効果的な特異的治療法の開発が望まれている。本研究ではマイオカインIL-15が筋分化やオートファジーの調整機構を介してサルコペニアの進展機序に与える影響に関する検討を行った。IL-15は骨格筋に対する運動効果の発現やオートファジーに関与していることが示された。骨格筋のオートファジーにおけるIL-15の制御は、オートファジー誘発性筋萎縮症に対する治療法の開発につながる可能性がある。

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Published: 2025-01-30  

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