The role of IL-22BP in asthma

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K20888
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0902:General internal medicine and related fields
• Research Institution: Okayama University
• Principal Investigator: Senoo Satoru 岡山大学, 医学部, 客員研究員 (00963026)
• Project Period (FY): 2022-08-31 – 2024-03-31
• Keywords: 気管支喘息 / IL-22BP / IL-22

Outline of Final Research Achievements

In order to clarify the role of IL-22BP in allergic airway response, we assessed IL-22BP-deficient mice. Airway hyperresponsiveness following HDM-induced airway inflammation was lower in IL-22BP-deficient mice compared to wild-type mice following sensitization and challenge with house dust mite (HDM). In contrast, airway inflammation including eosinophil and lymphocyte numbers in BAL fluid were not different between two strains of mice following sensitization and challenge with HDM. Thus, our data suggest that IL-22BP plays a critical role for the development of allergen-induced airway hyperresponsiveness without affecting airway inflammation.

Free Research Field

アレルギー性気道反応

Academic Significance and Societal Importance of the Research Achievements

気管支喘息のアレルギー性気道反応、特に気道過敏性亢進は喘息の重要なフェノタイプのひとつであるがそのメカニズムについては不明な点が多い。我々の研究成果から、IL-22BPが気道過敏性亢進に促進的に働いており、IL-22BPの制御が新たな喘息治療として有用である可能性が示唆された。