Exercise-induced changes in metabolites on prostate cancer progression.

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K20959
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0906:Surgery related to the biological and sensory functions and related fields
• Research Institution: Osaka University
• Principal Investigator: Oka Toshiki 大阪大学, 医学部附属病院, 医員 (60964385)
• Project Period (FY): 2022-08-31 – 2024-03-31
• Keywords: 前立腺癌 / 運動

Outline of Final Research Achievements

The incidence of prostate cancer is on the rise due to the westernization of diets and the aging of the population. Prostate cancer is largely related to lifestyle, and moderate exercise is known to improve the prognosis of prostate cancer. However, the mechanism is unknown.
In this study, we examined the effects of exercise on the progression of prostate cancer using mouse models of prostate cancer, with a particular focus on exercise-induced changes in metabolites.
First, prostate cancer model mice were divided into normal and exercise groups and reared until 22 weeks of age. As a result, the exercise group showed a significant reduction in prostate cancer. We also found that the profile of metabolites in prostate cancer tissue was significantly changed by exercise.

Free Research Field

前立腺癌

Academic Significance and Societal Importance of the Research Achievements

疫学的に証明されていた運動による前立腺癌抑制効果を基礎実験において証明した当研究の意義は大きい。また、前立腺癌組織中の代謝物の変化を特定できたことの学術的意義も大きい。今後は変化した代謝物が、前立腺癌の進展に及ぼす影響について検証を行う。また、当該代謝物のバイオマーカーとしての利用や治療ターゲットとしての妥当性についても検証していく。