2023 Fiscal Year Annual Research Report
Development of immunomodulatory scaffolds for tissue regeneration
| Project/Area Number |
22K20989
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2022-08-31 – 2024-03-31
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| Keywords | Scaffolds / Synthetic polymers / Biomaterials / Cells / Inflammation |
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| Outline of Annual Research Achievements |
Poly(lactic acid/caprolactone) copolymer (PLCL) were used to fabricate synthetic scaffold materials, and compared with commercial animal collagen-derived scaffolds. Human fibroblasts seeded onto the PLCL scaffolds expressed higher levels of genes associated with wound healing, in comparison with commercial animal collagen-derived scaffolds. In an animal model, PLCL scaffolds showed slower degradation when compare to collagen scaffolds, extending the scaffold function for longer time. Additionally, extensive inflammation was associated with collagen scaffolds, but less inflammation was associated with the PLCL synthetic scaffold. The results obtained in this study indicates that a PLCL scaffold is an useful alternative to animal collagen-derived scaffolds.
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