Relationship of beta-adrenergic receptor signaling to the development of cardiac disease caused by periodontal disease.

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K21003
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Tsurumi University
• Principal Investigator: Matsuo Ichiro 鶴見大学, 歯学部, 学部助手 (40962907)
• Project Period (FY): 2022-08-31 – 2024-03-31
• Keywords: 歯周病原細菌 / 内毒素 / 交感神経系

Outline of Final Research Achievements

It has been reported that a higher percentage of patients with periodontal disease have abnormal heart rate variability (HRV), an indicator of sympathetic nervous system activation, which is a cause of cardiac disease, but the detailed pathogenic mechanism is unknown. To measure sympathetic nervous system activation caused by periodontal disease, we performed HRV analysis (LF/HF) in control and periodontitis-derived endotoxin (PG-LPS) groups using mice. After serum collection, serum angiotensin ll, which indicates sympathetic nervous system activity, was measured. All of them were significantly higher in the PG-LPS-treated group than in the control group. These results suggest that chronic administration of PG-LPS may be involved in the development of cardiac disease due to sustained activation of the sympathetic nervous system.

Free Research Field

歯周病学

Academic Significance and Societal Importance of the Research Achievements

歯周病は心疾患の発症に関与することが示唆されているが、その発症メカニズムについては不明な点が多い。特に歯周病が交感神経系の異常亢進による心疾患発症との関連についての知見は少ない。本研究ではマウスに歯周病原細菌由来内毒(PG-LPS）を投与したところ、投与前と比較して交感神経系の活性化の指標である心拍数・LF/HF ratioは有意に上昇し、交感神経系の活性を示す血清アンギオテンシンllも上昇した。以上の結果からPG-LPSの慢性投与は交感神経系の持続的な活性化による心疾患発症に関与している可能性が示唆された。これらの研究成果は歯周病予防は心疾患発症予防にも繋がることが示された。