Elucidation of the function of p130Cas in ameloblast polarization

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K21017
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Kyushu University
• Principal Investigator: Inoue Akane 九州大学, 大学病院, 医員 (70967752)
• Project Period (FY): 2022-08-31 – 2024-03-31
• Keywords: エナメル芽細胞 / 極性化

Outline of Final Research Achievements

Ameloblast, which are involved in enamel formation, are known to undergo morphological changes and acquire function during their differentiation process. Since ameloblast secrete enamel matrix in one direction after differentiation, it is thought that the polarization process is important. Previous studies have shown that the p130Cas is important for the polarization of ameloblast. However, the detailed molecular function is unknown. In this study, a p130Cas knockout cell line is constructed and attempted to elucidate the molecular mechanism by observing polarization in an in vitro.

Free Research Field

歯科矯正学

Academic Significance and Societal Importance of the Research Achievements

歯は上皮－間葉相互作用により形成される器官として知られており、複数の細胞種から形成されることから、その再生技術の開発は困難な状況にある。エナメル芽細胞はエナメル質を形成する上で、その極性化プロセスが重要であると考えられるが、その詳細な分子メカニズムは不明である。本研究の極性化解析モデルにより、新たな分子機序の解明に寄与できる可能性がある。