Investigation of a novel mechanism of cleft palate pathogenesis via JAK2/STAT pathway and search for a treatment

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K21036
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Osaka University
• Principal Investigator: Yoshida Naoki 大阪大学, 歯学部附属病院, 医員 (30965273)
• Project Period (FY): 2022-08-31 – 2024-03-31
• Keywords: 口蓋裂 / JAK2/STAT経路

Outline of Final Research Achievements

The pathogenesis of cleft palate remains unclear.In this study, we used a JAK2/STAT pathway-specific inhibitor (AG490) to analyze the mechanism by which inhibition of the JAK2/STAT pathway causes loss of medial edge epithelium (MEE cells).The study also aimed to find a compound that would be a new drug for cleft palate due to inhibition of the JAK2/STAT pathway.It was found that AG490 treatment suppressed the expression of the tumor suppressor gene p21 in MEE cells. In addition, folic acid rescued cleft palate due to inhibition of the JAK2/STAT pathway.New clues have been found to a new treatment for cleft palate inhibition of the JAK2/STAT pathway.

Free Research Field

歯科矯正学

Academic Significance and Societal Importance of the Research Achievements

口蓋突起の癒合におけるJAK2/STAT経路の役割についての解析はこれまで報告がなく、本研究成果は口蓋突起の上皮の癒合に着目し、口蓋突起の癒合で最も重要な経路のTGF-bシグナルでは説明できない口蓋裂発症メカニズムを解析しようとする点で非常に高い学術的意義がある。また、多因子性の疾患である口蓋裂発症のメカニズムの中でJAK2/STAT経路の異常から発症する口蓋裂の新しい予防治療法の開発につながる点で社会的意義を有している。