Role of stress-induced inflammatory factor cPLA2 in hyaline degeneration and tooth root resorption

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K21045
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Nagasaki University
• Principal Investigator: ichinose yuika 長崎大学, 医歯薬学総合研究科(歯学系), 客員研究員 (80967589)
• Project Period (FY): 2022-08-31 – 2024-03-31
• Keywords: 歯根吸収 / cPLA2

Outline of Final Research Achievements

When orthodontic force is applied, the periodontal ligament tissue on the compression side becomes a hypoxic environment because the blood vessels are compressed and the blood supply is reduced. Recently, it has become clear that hyaline degeneration (ischemic cell death) caused by the hypoxic environment and the differentiation and activation of osteoclasts and odontoclasts are deeply involved in the process of root resorption. Therefore, we used a cPLA2 inhibitor in this study to know whether cPLA2 is involved in root resorption. Administration of cPLA2 inhibitors tended to suppress root resorption, suggesting that cPLA2 is involved in the initiation of root resorption.

Free Research Field

歯科矯正学

Academic Significance and Societal Importance of the Research Achievements

歯科矯正治療において、歯根吸収は最も頻繁に認められる副作用の一つであり、歯根吸収が甚だしい場合には抜歯に至ることもあるため、多くの歯科医師は、一刻も早い歯根吸収の予防法の確立を求めている。しかし、世界的にもその原因やメカニズムはほとんど解明されておらず、歯根吸収の予測法や、その予防法もないのが現状である。よって、本研究においてcPLA2阻害による歯根吸収への抑制効果が立証され、そのメカニズムの一端が解明されれば、歯根吸収の研究において大きな一歩となる。