Function of the transcription regulator Mkx in orthodontic tooth movement.

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K21054
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: Miyazaki Takayuki 東京医科歯科大学, 東京医科歯科大学病院, 特任助教 (60964971)
• Project Period (FY): 2022-08-31 – 2024-03-31
• Keywords: シングルセル解析 / OTM / PDL / Mohawk homeobox / Mkx

Outline of Final Research Achievements

The periodontal ligament plays an important role in orthodontic tooth movement, but its molecular mechanism is still unknown. We have previously reported that Mohawk homeobox (Mkx), a transcription factor specific to the periodontal ligament, may function as a mechanosensor in orthodontic force-mediated tooth movement via induction of RANKL and osteoclast differentiation, using Mkx deletion rats generated with the CRISPR / Cas9 system We have reported the possibility that Mkx functions as a mechanosensor in tooth movement via induction of RANKL and osteoclast differentiation. In this study, we aimed to elucidate the complexity of the periodontal ligament, which is composed of diverse cells, and the relationships among genes involved in the organization, and to elucidate the effects of Mkx on mechanical stress-induced bone remodeling by single cell analysis.

Free Research Field

歯科矯正学

Academic Significance and Societal Importance of the Research Achievements

Mkxのにおける恒常性維持、骨リモデリングへの作用を解明することは、歯科矯正学的な歯の移動が阻害される骨性癒着などの歯根膜の病的状態に対する新たな治療法への新領域開発の礎となると考えられる。