Elucidation of the function of CGRP in the healing process of periodontal tissue

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K21059
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Osaka University
• Principal Investigator: Takeshita Noboru 大阪大学, 歯学部附属病院, 医員 (80967688)
• Project Period (FY): 2022-08-31 – 2024-03-31
• Keywords: CGRP / RAMP1 / 歯周組織再生

Outline of Final Research Achievements

Calcitonin Gene-Related Peptide (CGRP) is a neuropeptide consisting of 37 amino acids produced by selective splicing of the calcitonin gene. Recently, many reports have suggested that CGRP plays important roles in immune cell regulation and bone metabolism. In this study, we used gene knockout mice of Ramp1, a specific component of the CGRP receptor, to analyze its effects on the destruction of periodontal tissue and the healing process. The resuls showed that alveolar bone recovery was delayed in Ramp1 gene-deficient mice compared to wild-type mice.

Free Research Field

歯周病学

Academic Significance and Societal Importance of the Research Achievements

三叉神経節で生成されるCGRPが歯周組織の治癒・再生に関与しているとの結果が得られた。本研究結果は、歯根膜における神経が従来知られてきた末梢における感覚受容のみならず、歯周組織の恒常性維持や組織修復に重要な機能を果たしていることを示しており、全身的にも神経系が組織の恒常性維持や骨代謝に大いに関与していることが示唆される。