Extracellular pH regulates bone turnover regulation by osteoocytes

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K21069
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0907:Oral science and related fields
• Research Institution: Showa University
• Principal Investigator: AMADA KAORI 昭和大学, 歯学部, 助教 (90966186)
• Project Period (FY): 2022-08-31 – 2024-03-31
• Keywords: 骨細胞 / 骨代謝 / 細胞外酸性化 / 骨のリモデリング

Outline of Final Research Achievements

The purpose of this study is to clarify how extracellular acidification affects bone metabolism by clarifying the effect of extracellular acidification on bone metabolism control by bone cells at the molecular level. We found that the expression and secretion of sclerostin and OPG by bone cells is promoted by extracellular acidification. Regarding the elucidation of the mechanism of extracellular acidification reception in bone cells, it is highly likely that GPR68/OGR1 is a receptor for extracellular acidification, and therefore it is thought that bone metabolism can be controlled by blocking GPR68/OGR1.

Free Research Field

骨代謝

Academic Significance and Societal Importance of the Research Achievements

骨細胞を酸性下に培養することで骨形成を抑制するスクレロスチンの発現が増加することが発見された。骨細胞の細胞外酸性化の受容体として、GPR68/OGR1の可能性が高いことが示唆されている。酸性環境下での骨代謝回転の制御を理解することは、がんの骨転移をはじめとする病的酸性化を生じる骨疾患に対する治療に有用な情報をもたらすことが期待され、臨床的意義は非常に大きい。