2023 Fiscal Year Final Research Report
In vitro study of the association between ALDH2 rs671 polymorphism and Acral Lentiginous Melanoma
| Project/Area Number |
22K21117
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| Research Category |
Grant-in-Aid for Research Activity Start-up
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| Allocation Type | Multi-year Fund |
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| Review Section |
0908:Society medicine, nursing, and related fields
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| Research Institution | Saga University |
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Principal Investigator |
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| Project Period (FY) |
2022-08-31 – 2024-03-31
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| Keywords | Melanoma / Melanin / Acetaldehyde / Ethanol / ALDH2 / rs671 |
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| Outline of Final Research Achievements |
Melanoma,is influenced by genetic factors like the ALDH2rs671 polymorphism and lifestyle choices.This study examined acetaldehyde's effect on melanin synthesis and gene expression in melanocytes, particularly in ALDH2rs671 carriers.
Treatment with acetaldehyde,α-Melanocyte stimulating hormone, and ethanol increased melanin synthesis and ALDH2 and Tyrosinase gene expression, suggesting pathways involving oxidative stress. These findings highlight genetic and lifestyle risk factors for Melanoma, especially in East Asians with a high frequency of ALDH2rs671.
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| Free Research Field |
Environmental Medicine
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| Academic Significance and Societal Importance of the Research Achievements |
The study underscores the roles of acetaldehyde, ethanol levels, and specific gene expressions in melanogenesis of Melanoma. It highlights the increased risk of melanoma and Melanoma by accumulating acetaldehyde from alcohol consumption,
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