An approach to elucidating the effects of voluntary and forced exercise using microdialysis method

2023 Fiscal Year Final Research Report

• Project/Area Number: 22K21257
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Multi-year Fund
• Review Section: 0909:Sports sciences, physical education, health sciences, and related fields
• Research Institution: Osaka Electro-Communication University
• Principal Investigator: Daisuke Matsunaga 大阪電気通信大学, 医療健康科学部, 特任講師 (30963508)
• Project Period (FY): 2022-08-31 – 2024-03-31
• Keywords: 自発運動 / 強制運動 / 脳内モノアミン / マイクロダイアリシス

Outline of Final Research Achievements

The purpose of this study was to clarify the immediate responses of voluntary and forced exercise to neurotransmitters (serotonin: 5-HT, noradrenaline: NA, and dopamine: DA) in the brain using the microdialysis method.
We tried to measure neurotransmitters in the brain during voluntary exercise using a cage specially designed for microdialysis measurement. It was very difficult to control the experimental animal with freely active. The nine rats for which measurements were performed, six were able to obtain data on neurotransmitters in the brain. However, through this study, improvements were made to the measurement method and an experimental method was established.

Free Research Field

行動神経科学

Academic Significance and Societal Importance of the Research Achievements

自発運動と強制運動の効果の違いは明らかとなっていないことが多い。マイクロダイアリシス法を用いて、自発運動と強制運動の効果を比較する実験は、国内外の先行研究の動向からみても先駆的であり、独創性も高いことからも、本研究において得られた自発運動用回転ホイールを用いた自発運動中の脳内神経伝達物質のデータは価値の高いものである。