2022 Fiscal Year Annual Research Report
Development of BioMEMS based on mechanochromic polymers
| Project/Area Number |
22F22318
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| Allocation Type | Single-year Grants |
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| Research Institution | The University of Tokyo |
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| Host Researcher |
杉原 加織 東京大学, 生産技術研究所, 講師 (60740800)
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| Foreign Research Fellow |
DAS BRATATI 東京大学, 生産技術研究所, 外国人特別研究員
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| Project Period (FY) |
2022-11-16 – 2025-03-31
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| Keywords | メカノクロミックポリマー / ポリジアセチレン / 原子間力顕微鏡 |
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| Outline of Annual Research Achievements |
The goal of the project is to develop a highly sensitive nano-force sensor to quantitatively detect and visualize friction forces using the force-sensing mechanism of a mechanochromic polymer, polydiacetylene, as it exhibits strong optical absorption and fluorescence properties upon exposure in different kind of mechanical stress. Due to its unique mechanical stress sensing mechanism PDA has potential to be used in a variety of sensing and imaging devices and biomedical applications. But so far the potential applications are based on macroscopic study, the color change as a function of quantitative external forces at nanoscale, has been understudied. Our conjecture is to establish quantitative correlation between fluorescence and forces at nanoscale. The main challenge is PDA reacts against forces lateral to the substrates due to its anisotropic structure, whereas standard AFM can quantify only vertical forces. Recently Sugihara Group has demonstrated the nano-friction force microscopy (FFM), a mode of AFM, where it can quantify lateral forces in addition to the standard vertical forces. [J. Phys. Chem. C, 122 (21), 11464-11474, 2018]. Their recent study showed that PDA uniquely detects lateral forces (friction forces) in nanonewton range. So, this mechanochormism property will accelerate the utilization of PDA to develop nano-force (friction force) sensor.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
We have used nano-friction force microscopy and fluorescence microscopy for quantitative detection and visualization of friction forces at nanoscale in Polydiacetylene (PDA) , and PDA/different kind of guest composites. For the preparation of the composites, we have collaborated with Prof. Yuya Oaki, Keio University.
1. Polydiacetylene/guest composites deposited on glass slide by Langmuir-Blodgett trough and the glass slide have characterized by XRD, ATR IR etc.
2. The glass slide have been scanned with different set points 30-100nN by friction force microscopy. Scratching PDA by an atomic force microscopy (AFM) tip makes it fluorescent reveals PDA is mechanochromic at nanoscale. Fluorescence increases before and after scratching (Fluorescence), lateral, vertical force map, are extracted from fluorescence microscopy, lateral, vertical deflection in AFM respectively.
3. The experimental data analysed by a written MATLAB program and obtained pixel by pixel correlation shows quantitative correlation between PDA fluorescence emission and local forces at nanoscale.
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| Strategy for Future Research Activity |
Next based on the results of previous fiscal year we will try to make nano-friction sensor that will “map” frictions in biomimetic finger prosthetics and finger limbs which is relatively small scale and inexpensive ones. The unique mechanosensitive properties of PDA can be used to visualize and quantitively detect force at nanoscale, macroscale and map the appropriate distribution of unknown pressure in prosthetics and help to modify pressure ulcer related problem in an amputee person. In prosthetics research, to measure physiological pressures quantitively are essential to maximize mobility and maintain limb tissue health.
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Research Products
(1 results)
