2022 Fiscal Year Annual Research Report
Stimuli-responsive porphyrin-polymer systems for biomedical and sensing applications
| Project/Area Number |
22F21764
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| Allocation Type | Single-year Grants |
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| Research Institution | National Institute for Materials Science |
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Principal Investigator |
Labuta Jan 国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, 主任研究員 (00720690)
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| Co-Investigator(Kenkyū-buntansha) |
VELYCHKIVSKA NADIIA 国立研究開発法人物質・材料研究機構, 国際ナノアーキテクトニクス研究拠点, 外国人特別研究員
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| Project Period (FY) |
2022-07-27 – 2024-03-31
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| Keywords | Polymers / Porphyrins / Phase separation / Sensing / Energy storage / Porosity |
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| Outline of Annual Research Achievements |
The purpose of this project is the design/synthesis and physicochemical characterization of photostable stimuli-responsive porphyrin-polymer conjugates based on the connection of hydrophilic biocompatible/biodegradable polymer with photoactive porphyrin unit. In FY2022, synthetic methods were established. Various porphyrin conjugates with biocompatible polyethylene glycol (PEG) and poly(N-isopropylacrylamide) (PNIPAM) were prepared. Basic characterization using NMR, UV-Vis, FTIR, DSC, SEM and TEM were performed. Detailed investigation of phase-separation properties of porphyrin-PNIPAM conjugates was undertaken. The system exhibits different structures below phase separation temperature ca. 32°C (i.e. 1D supramolecular polymer) and above (i.e. large globular structures). These structures are further tunable by pH.
Also, highly porous functional materials (with surface area >3000 m2/g) were prepared by thermal treatment of suitable polymers.
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| Current Status of Research Progress |
Current Status of Research Progress
2: Research has progressed on the whole more than it was originally planned.
Reason
The research plan is in progress as scheduled.
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| Strategy for Future Research Activity |
Further, the properties of obtained porphyrin-polymer conjugates will be investigated for their response to various external stimuli (pH, temperature, etc.). The thermodynamic model of their phase-separation behaviour will be developed.
The porous functional materials obtained by thermal treatment of suitable polymers will be tested for catalytic, adsorption, sensing and energy storage applications.
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