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2023 Fiscal Year Annual Research Report

Stimuli-responsive porphyrin-polymer systems for biomedical and sensing applications

Research Project

Project/Area Number 22KF0385
Allocation TypeMulti-year Fund
Research InstitutionNational Institute for Materials Science

Principal Investigator

Labuta Jan  国立研究開発法人物質・材料研究機構, ナノアーキテクトニクス材料研究センター, 主任研究員 (00720690)

Co-Investigator(Kenkyū-buntansha) VELYCHKIVSKA NADIIA  国立研究開発法人物質・材料研究機構, ナノアーキテクトニクス材料研究センター, 外国人特別研究員
Project Period (FY) 2023-03-08 – 2024-03-31
KeywordsPolymers / Hydrogel / Energy storage / Supercapacitor / Porosity / Fluorescence / NADPH / Bioorthogonal chemistry
Outline of Annual Research Achievements

The investigated objectives were stretched to the field of hydrogels. We synthesized an ultrahigh surface area hierarchically porous carbon materials, prepared by potassium carbonate activation of polyacrylamide-hydroxy propyl cellulose hydrogel at high temperatures (500-900 °C) and explored their energy storage performances. The carbon material obtained has an ultrahigh surface area of 3387.2 m2 g-1 and a large pore volume of 1.963 cm3 g-1. The material showed an excellent supercapacitance performance (545.5 F g-1 at 1 A g-1 current density) with superior rate capability and an outstanding cycling stability of 96.3% after 5000 charge-discharge cycles. The electrochemical properties indicate that hierarchically porous carbons obtained from hydrogels are promising materials for high-performance supercapacitor applications.

Furthermore, we have used the kinetic schemes developed in 2022 (Scientific Reports, 2022, 12:17369, 1-15) to study the kinetics of the ubiquinone-rhodol (Q-Rh) fluorescence probe. The Q-Rh probe was used to monitor the activation of nicotinamide adenine (NADPH) within HeLa cancer cells. This activation can be further promoted (enhanced) by Ir(III)-complex (i.e. [(η5-C5Me5)Ir(phen)(H2O)]2+). The activation of NADPH with simultaneous monitoring of this process can exploit unique chemical reactions within cells. This concept stands in contrast to the conventional, widely recognized concept of biorthogonal chemistry. We have coined the term “bioparallel chemistry” to differentiate this approach.

  • Research Products

    (4 results)

All 2024 2023

All Journal Article (2 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 2 results,  Open Access: 1 results) Presentation (2 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Ultrahigh Surface Area Hierarchically Porous Carbon Materials from Polyacrylamide-Cellulose Hydrogel for High-Performance Supercapacitors2024

    • Author(s)
      Velychkivska Nadiia、Golunova Anna、Panda Atanu、Shinde Pragati A.、Ma Renzhi、Ariga Katsuhiko、Yamauchi Yusuke、Hill Jonathan P.、Labuta Jan、Shrestha Lok Kumar
    • Journal Title

      ACS Applied Energy Materials

      Volume: 7 Pages: 2906~2917

    • DOI

      10.1021/acsaem.4c00141

    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Kinetic study of NADPH activation using ubiquinone-rhodol fluorescent probe and an Ir(III)-complex promoter at the cell interior2023

    • Author(s)
      Komatsu Hirokazu、Velychkivska Nadiia、Shatan Anastasiia B.、Shindo Yutaka、Oka Kotaro、Ariga Katsuhiko、Hill Jonathan P.、Labuta Jan
    • Journal Title

      RSC Advances

      Volume: 13 Pages: 34012~34019

    • DOI

      10.1039/d3ra05412h

    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Physicochemical study of water-soluble porphyrin-PNIPAM4 conjugates: pH-dependent behavior and phase-separation phenomenon2023

    • Author(s)
      Nadiia Velychkivska
    • Organizer
      7th International Symposium Frontiers in Polymer Science
  • [Presentation] Physicochemical study of water-soluble porphyrin-PNIPAM4 conjugates: phase-separation phenomenon and pH-responsiveness2023

    • Author(s)
      Nadiia Velychkivska
    • Organizer
      6th International Conference on Recent Trends in Materials and Devices (ICRTMD 2023)
    • Int'l Joint Research

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Published: 2024-12-25  

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