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2023 Fiscal Year Annual Research Report

Oral nanoparticle formulations for allergy treatment via efficient induction of immune tolerance

Research Project

Project/Area Number 22KJ2442
Allocation TypeMulti-year Fund
Research InstitutionKyushu University

Principal Investigator

李 晋廷  九州大学, システム生命科学府, 特別研究員(DC2)

Project Period (FY) 2023-03-08 – 2024-03-31
Keywordsallergy treatment / nanoparticle / tolerance immunity / DDS
Outline of Annual Research Achievements

In the current year, my research focusing on the development of nanoparticles inducing immune tolerance for allergy treatment has made significant progress. Herein, I present an overview of my research achievements for this year:
1. Background: The number of allergy patients is on the rise. Despite immunotherapy being the only curative treatment for allergies, its high incidence of side effects and low efficacy over a treatment period of more than three years have rendered the therapy less than satisfactory. Therefore, the development of a safe and efficient treatment method has become urgent. 2. Preparation: Traditional treatment methods involve the direct administration of antigens to patients, leading to the side effects. To address this issue, I encapsulated the antigen with hydrogel nanoparticles (NP) to prevent side effects. Additionally, I modified the NP with targeting ligands to DC to enhance treatment efficiency. As results, the size of NP was adjusted to 200 nm. 3. In Vitro: NP with DC-targeting ligands significantly improved the DC uptake efficiency and increased the levels of IL-10 released by DCs, indicating their significant anti-inflammatory capabilities. 4. In Vivo: Regarding safety, NP exhibited significantly reduced binding affinity with IgE. Furthermore, repeated subcutaneous injections of NP did not induce the production of anti-drug antibodies, such as IgG and IgM. More, NP showed significant therapeutic effects on allergic model mice by decreasing IgE and the number of eosinophils.

  • Research Products

    (2 results)

All 2024 2023

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Oral Administration of PLGA Nanoparticles to Deliver Antisense Oligonucleotides to Inflammatory Lesions in the Gastrointestinal Tract2024

    • Author(s)
      Yagi Yuta、Liu Yiwei、Li Jinting、Shimada Shunsuke、Ohkouchi Munetaka、Taguchi Yasushi、Nii Teruki、Mori Takeshi、Katayama Yoshiki
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 47 Pages: 848~855

    • DOI

      10.1248/bpb.b23-00769

    • Peer Reviewed
  • [Journal Article] Safe and efficient oral allergy immunotherapy using one-pot-prepared mannan-coated allergen nanoparticles2023

    • Author(s)
      Li Shunyi、Toriumi Hiroki、Takahashi Daisuke、Kamasaki Tomoko、Fujioka Yoichiro、Nagatoishi Satoru、Li Jinting、Liu Yiwei、Hosokawa Takanatsu、Tsumoto Kouhei、Ohba Yusuke、Katayama Yoshiki、Murakami Daisuke、Hase Koji、Mori Takeshi
    • Journal Title

      Biomaterials

      Volume: 303 Pages: 122381~122381

    • DOI

      10.1016/j.biomaterials.2023.122381

    • Peer Reviewed

URL: 

Published: 2024-12-25  

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