Bioinorganic Chemistry of Oxidoreductases having Unique Active Site Clusters

2015 Fiscal Year Final Research Report

• Project/Area Number: 23000007
• Research Category: Grant-in-Aid for Specially Promoted Research
• Allocation Type: Single-year Grants
• Review Section: Science and Engineering; Chemistry
• Research Institution: Nagoya University
• Principal Investigator: TATSUMI Kazuyuki 名古屋大学, 物質科学国際研究センター, 特任教授 (10155096)
• Co-Investigator(Renkei-kenkyūsha): MATSUMOTO Tsuyoshi 名古屋大学, トランスフォーマティブ生命分子研究所, 特任教授 (50311717) ; FUJITA Yuichi 名古屋大学, 生命理学研究科, 准教授 (80222264) ; OHKI Yasuhiro 名古屋大学, 大学院理学研究科, 准教授 (10324394)
• Project Period (FY): 2011 – 2015
• Keywords: 酸化還元金属酵素 / 金属クラスター / ニトロゲナーゼ / ヒドロゲナーゼ / アセチルCoA 合成酵素 / 光化学系II酸素発生中心 / プロトクロロフィリド還元酵素

Outline of Final Research Achievements

Metalloenzymes are essential for all organisms on earth, and their metal-incorporating active centers play the major roles in regulating highly efficient/selective enzymatic functions. This research project has focused on the unprecedented cluster active sites of nitrogenases, photosystem II, hydrogenases, and acetyl CoA synthase etc., and we have succeeded in the chemical synthesis of the complicated and unstable inorganic cores of these cluster active sites using our newly-developed concept of cluster synthesis. Based on the achievements, we have unfolded new bioinorganic chemistry and established a scientific basis for chemical understanding of the enzymatic functions.

Free Research Field

化学