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2015 Fiscal Year Annual Research Report

極低摩擦・極低摩耗生体関節に学ぶ生体規範超潤滑ハイドロゲル人工軟骨の実用化

Research Project

Project/Area Number 23000011
Research InstitutionKyushu University

Principal Investigator

村上 輝夫  九州大学, バイオメカニクス研究センター, 特命教授 (90091347)

Co-Investigator(Kenkyū-buntansha) 澤田 廉士  九州大学, 工学(系)研究科(研究院), 教授 (40380589)
澤江 義則  九州大学, 工学(系)研究科(研究院), 教授 (10284530)
岡崎 賢  九州大学, 大学病院, 講師 (10398092)
松田 秀一  京都大学, 医学(系)研究科(研究院), 教授 (40294938)
鈴木 淳史  横浜国立大学, 環境情報研究院, 教授 (90162924)
Project Period (FY) 2013 – 2015
Keywordsハイドロゲル人工軟骨 / 生体関節多モード潤滑 / 生体規範人工関節 / 生体医工学 / トライボロジー
Outline of Annual Research Achievements

人工関節の摩耗・摩擦低減を実現するために生体関節の構造・機構・機能の理解を深め、その成果を反映させた高機能ハイドロゲル人工軟骨の臨床実用化技術の構築を目指して研究に取組んだ。
【1】生体関節の多モード適応潤滑機構の解明(1)関節軟骨の構造・物性評価と潤滑膜形成機構の解明 : 摩擦・可視化試験や吸着評価試験により関節液成分の吸着特性を明確化するとともに、主要4成分の最適組成による境界潤滑効果を明示した。(2)関節軟骨の摩擦挙動の実測と固液二相有限要素解析 : 固液二相有限要素解析や流体圧実測試験に基づき、軟骨液相流体圧による荷重支持率の評価と固相摩擦の考慮により摩擦予測と実測値の合致を確認した。軟骨表層の繊維強化が固液二相潤滑に有効であることを示した。(3)レーザードップラー流速計により血清希釈溶液中の成分(0.2μmより小さい蛋白凝集体など)による散乱信号により流速を評価できることを確認した。
【2】生体規範超潤滑ハイドロゲル人工軟骨の実用化 (1)PVAハイドロゲルのシート試験片に対して単軸引張疲労試験を行い、ハイブリッドゲルにおける高強度を確認した。大変形繰返し試験が可能な疲労試験機を開発した。ゲルのクリープ変形や配向による強化など複雑な現象を考慮した試験法の提案については今後の課題となった。(2)PVAハイドロゲルの改質高機能化 : a)繰返凍結・解凍FTゲルにおいて一方向凍結により高強度・高膨潤化の両立の実現を示した。b)キャストドライ法PVAのナノ構造・界面制御や、積層化技術開発に取組み、物性改善と低摩擦性を見出した。c)2種のゲルの最適組合せのハイブリッドゲルにおいて2段階乾燥処理による最適構造ゲルにおいて模擬関節液潤滑下における摩擦摩耗特性の高性能化を確認できた。アルコール滅菌によるゲルの変性とトライボ特性の変化を確認し、γ線照射処理の場合に特性変化を低減できることを確認できた。(3)摩耗粉へのマクロファージ反応 : 株化単球細胞由来マクロファージによる摩耗粉応答の評価により3種のPVAゲル全てにおいて異物応答が見られないことを確認した。(4)人工関節の臨床課題の解析評価を行い各種の改善指針を得た。ハイブリッド人工軟骨・人工骨複合体の家兎膝関節埋入試験を行い、12週での生体適合性と機能維持を確認し、ゲル表面破損・硬化現象の改善を確認した。

  • Research Products

    (101 results)

All 2016 2015 Other

All Journal Article (29 results) (of which Peer Reviewed: 29 results,  Open Access: 7 results) Presentation (67 results) (of which Int'l Joint Research: 44 results,  Invited: 14 results) Book (3 results) Remarks (1 results) Funded Workshop (1 results)

  • [Journal Article] Evaluation of Lubrication Property of Poly (vinyl alcohol) Hybrid Gel for Artificial Articular Cartilage2016

    • Author(s)
      S. Yarimitsu, A. Yoshida, S. Sasaki, T. Murakami, A. Suzuki
    • Journal Title

      Tribology Online

      Volume: 11

    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of wear suppression for phospholipid polymer-grafted ultra-high molecular weight polyethylene at concentrated contact2016

    • Author(s)
      S. Uehara, S. Yarimitsu, T. Moro, M. Kyomoto, K. Watanabe, S. Tanaka, K. Ishihara and T. Murakami
    • Journal Title

      Tribology International

    • Peer Reviewed
  • [Journal Article] Comparison of the impact of closing wedge versus opening wedge high tibial osteotomy on proximal tibial deformity and subsequent revision to total knee arthroplasty2016

    • Author(s)
      Kuwashima U, Tashiro Y, Okazaki K, Mizu-uchi H, Hamai S, Murakami K, Iwamoto Y
    • Journal Title

      Knee Surg Sports Traumatol Arthrosc

    • Peer Reviewed / Open Access
  • [Journal Article] 人工関節材料に吸着した蛋白質膜のせん断強さ評価生体軟骨を摩擦相手面としたハイドロゲル人工軟骨の潤滑性評価2016

    • Author(s)
      中嶋和弘, 澤江義則, 村上 輝夫
    • Journal Title

      臨床バイオメカニクス

      Volume: 37

    • Peer Reviewed
  • [Journal Article] 人工軟骨候補材料としての繊維強化PVAハイドロゲルの固液二相性モデルによる解析2016

    • Author(s)
      坂井伸朗, 橋本知依, 鎗光清道, 澤江義則, 小森望充, 村上輝夫
    • Journal Title

      臨床バイオメカニクス

      Volume: 37

    • Peer Reviewed
  • [Journal Article] 生体軟骨を摩擦相手面としたハイドロゲル人工軟骨の潤滑性評価2016

    • Author(s)
      鎗光清道, 佐々木沙織, 村上輝夫
    • Journal Title

      臨床バイオメカニクス

      Volume: 37

    • Peer Reviewed
  • [Journal Article] 水潤滑液中に溶出したポリビニルアルコール(PVA)分子がPVA水和ゲルの摩耗に与える影響2016

    • Author(s)
      小俣誠二, 澤江 義則, 村上 輝夫
    • Journal Title

      臨床バイオメカニクス

      Volume: 37

    • Peer Reviewed
  • [Journal Article] Contact stress analysis of the anterior tibial post in bi-cruciate stabilized and mobile-bearing posterior stabilized total knee arthroplasty designs2016

    • Author(s)
      Kuwashima U, Hamai S, Okazaki K, Ikebe S, Higaki H, Mizu-uchi H, Akasaki Y, Murakami K, Iwamoto Y
    • Journal Title

      J Mech Behav Biomed Mater

      Volume: 60 Pages: 460-467

    • DOI

      10.1016/j.jmbbm.2016.03.003

    • Peer Reviewed
  • [Journal Article] Factors Influencing the Swelling and Elution Properties of Poly (vinylalcohol) Cast Gels2016

    • Author(s)
      Saori Sasaki and Atsushi Suzuki
    • Journal Title

      Polymers for Advanced Technologies

      Volume: 27 Pages: 318-324

    • DOI

      10.1002/pat.3643

    • Peer Reviewed
  • [Journal Article] Frictional properties of physically cross-linked PVA hydrogels as artificial cartilage2016

    • Author(s)
      Saori Sasaki, Teruo Murakami, Atsushi Suzuki
    • Journal Title

      Biosurface and Biotribology

      Volume: 2 Pages: 11-17

    • DOI

      10.1016/j.bsbt.2016.02.002

    • Peer Reviewed / Open Access
  • [Journal Article] A functional effect of the superficial mechanical properties of articular cartilage as a load bearing system in a sliding condition2016

    • Author(s)
      N. Sakai, C. Hashimoto, S. Yarimitsu, Y. Sawae, M. Komori, T. Murakami
    • Journal Title

      Biosurface and Biotribology

      Volume: 2 Pages: 26-39

    • DOI

      10.1016/j.bsbt.2016.02.004

    • Peer Reviewed / Open Access
  • [Journal Article] Evaluation of Lubrication Properties of Hydrogel Artificial Cartilage Materials for Joint Prosthesis2016

    • Author(s)
      S. Yarimitsu, S. Sasaki, T. Murakami, A. Suzuki
    • Journal Title

      Biosurface and Biotribology

      Volume: 2 Pages: 40-47

    • DOI

      10.1016/j.Bsbt.2016.02.005

    • Peer Reviewed / Open Access
  • [Journal Article] In vivo kinematics of healthy male knees during squat and golf swing using image-matching techniques2016

    • Author(s)
      Murakami K, Hamai S, Okazaki K, Ikebe S, Shimoto T, Hara D, Mizu-Uchi H, Higaki H, Iwamoto Y
    • Journal Title

      Knee

      Volume: 23 Pages: 221-226

    • DOI

      10.1016/j.knee.2015.08.004

    • Peer Reviewed
  • [Journal Article] Special Issue Editorial : Hydrogels in Biomedical Use2015

    • Author(s)
      T. Murakami
    • Journal Title

      Proc IMechE PartH : J Engineering in Medicine

      Volume: 229 Pages: 825-827

    • DOI

      10.1177/0954411915616528pih.sagepub.com

    • Peer Reviewed
  • [Journal Article] Swelling and mechanical properties of physically crosslinked poly (vinyl alcohol) hydrogels2015

    • Author(s)
      A. Suzuki and S. Sasaki
    • Journal Title

      Proc IMechE PartH : J Engineering in Medicine

      Volume: 229 Pages: 828-844

    • DOI

      10.1177/0954411915615469pih.sagepub.com

    • Peer Reviewed
  • [Journal Article] Biphasic and boundary lubrication mechanisms in artificial hydrogel cartilage : A review2015

    • Author(s)
      T. Murakami, S. Yarimitsu, K. Nakashima, N. Sakai, T. Yamaguchi, Y. Sawae and A. Suzuki
    • Journal Title

      Proc IMechE PartH : J Engineering in Medicine

      Volume: 229 Pages: 864-878

    • DOI

      10.1177/0954411915611160pih.sagepub.com

    • Peer Reviewed
  • [Journal Article] ポリビニルアルコールキャストドライゲルの乾燥条件が摩擦特性に及ぼす影響2015

    • Author(s)
      佐々木沙織、鎗光清道、村上輝夫、鈴木淳史
    • Journal Title

      高分子論文集

      Volume: 72 Pages: 760-764

    • DOI

      10.1295/koron.2015-0036

    • Peer Reviewed
  • [Journal Article] 人工関節の次世代技術2015

    • Author(s)
      村上輝夫
    • Journal Title

      トライボロジスト

      Volume: 60 Pages: 706-711

    • Peer Reviewed
  • [Journal Article] 加工痕の弾性回復が人工関節用ポリエチレンの摩耗に及ぼす影響2015

    • Author(s)
      趙 昌熙, 村上輝夫, 澤江義則
    • Journal Title

      臨床バイオメカニクス

      Volume: 36 Pages: 181-187

    • Peer Reviewed
  • [Journal Article] ハイドロゲル人工軟骨の生体内固定法と安定性の評価2015

    • Author(s)
      鎗光清道, 中嶋和弘, 村上輝夫, 岡崎 賢, 松田秀一, 岩本幸英
    • Journal Title

      臨床バイオメカニクス

      Volume: 36 Pages: 201-206

    • Peer Reviewed
  • [Journal Article] An Estimation of Mechanical Properties of Articular Cartilage for Biphasic Finite Element Analyses2015

    • Author(s)
      Nobuo Sakai, Yuichiro Hagihara, Chie Hashimoto, Mochimitsu Komori, Yoshinori Sawae, Teruo Murakami
    • Journal Title

      Journal of Biomechanical Science and Engineering(JBSE)

      Volume: 10 Issue: 4 Pages: 228

    • DOI

      10.1299/jbse.15-00228

    • Peer Reviewed / Open Access
  • [Journal Article] Influences of dehydration and rehydration on the lubrication properties of phospholipid polymer-grafted cross-linked polyehtylene2015

    • Author(s)
      S. Yarimitsu, T. Moro, M. Kyomoto, K. Watanabe, S. Tanaka, K. Ishihara, T. Murakami
    • Journal Title

      Proc IMechE, Part H : J Engineering in Medicine

      Volume: 229 Issue: 7 Pages: 506-514

    • DOI

      10.1177/0954411915588969

    • Peer Reviewed
  • [Journal Article] Correction of coronal alignment correlates with reconstruction of joint height in unicompartmental knee arthroplasty2015

    • Author(s)
      Kuwashima U, Okazaki K*, Tashiro Y, Mizu-Uchi H, Hamai S, Okamoto S, Murakami K, Iwamoto Y
    • Journal Title

      Bone Joint Res

      Volume: 4 Pages: 128-133

    • DOI

      10.1302/2046-3758.48.2000416

    • Peer Reviewed
  • [Journal Article] Kinematic alignment produces near-normal knee motion but increases contact stress after total knee arthroplasty : A case study on a single implant design.2015

    • Author(s)
      Ishikawa M, Kuriyama S, Ito H, Furu M, Nakamura S, Matsuda S.
    • Journal Title

      Knee

      Volume: 22 Pages: 206-212

    • DOI

      10.1016/j.knee.2015.02.019

    • Peer Reviewed
  • [Journal Article] Distal femoral condyle is more internally rotated to the patellar tendon at 90 degrees of flexion in normal knees.2015

    • Author(s)
      Kawahara S, Okazaki K, Matsuda S, Nakahara H, Okamoto S, Iwamoto Y
    • Journal Title

      J Orthop Surg Res

      Volume: 10 Pages: 54

    • DOI

      10.1186/s13018-015-0197-5.

    • Peer Reviewed
  • [Journal Article] Posterior tibial slope and femoral sizing affect posterior cruciate ligament tension in posterior cruciate-retaining total knee arthroplasty2015

    • Author(s)
      Kuriyama S, Ishikawa M, Nakamura S, Furu M, Ito H, Matsuda S
    • Journal Title

      Clin Biomech

      Volume: 30 Pages: 676-81

    • DOI

      10.1016/j.clinbiomech.2015.05.006.

    • Peer Reviewed
  • [Journal Article] Analysis of the Flexion Gap on In Vivo Knee Kinematics Using Fluoroscopy.2015

    • Author(s)
      Nakamura S, Ito H, Yoshitomi H, Kuriyama S, Komistek RD, Matsuda S.
    • Journal Title

      J Arthroplasty

      Volume: 30 Pages: 1237-42

    • DOI

      10.1016/j.arth.2015.01.046.

    • Peer Reviewed
  • [Journal Article] A novel method to control the elution behavior of PVA cast gels2015

    • Author(s)
      S. Sasaki and A. Suzuki
    • Journal Title

      Macromolecular Symposia

      Volume: 358 Pages: 170-175

    • DOI

      10.1002/pat.3643

    • Peer Reviewed
  • [Journal Article] Effectofpoly(vinylalcohol)(PVA)wearparticlesgeneratedinwaterlubricantonimmuneresponseofmacrophage2015

    • Author(s)
      S. Omata, Y. Sawae and T. Murakami
    • Journal Title

      Biosurface and Biotribology

      Volume: 1 Pages: 71-79

    • DOI

      10.1016/j.bsbt.2015.02.003

    • Peer Reviewed / Open Access
  • [Presentation] Evaluation of Friction and Wear Behavior of PVA Hydrogels as Artificial Articular Cartilage Material2016

    • Author(s)
      S. Yarimitsu, A. Yoshida, S. Sasaki, T. Murakami, A. Suzuki
    • Organizer
      ORS 2016 Annual Meeting
    • Place of Presentation
      ディズニーコロナドスブリングリゾート(アメリカ合衆国フロリダ州)
    • Year and Date
      2016-03-07
    • Int'l Joint Research
  • [Presentation] 物理架橋PVAゲルの摩擦特性に及ぼすガンマ線照射の影響2016

    • Author(s)
      佐々木沙織、小俣誠二、村上輝夫、長澤尚胤、田口光正、鈴木淳史
    • Organizer
      2016年 日本生体医工学会九州支部学術講演会
    • Place of Presentation
      佐賀大学(佐賀県佐賀市)
    • Year and Date
      2016-03-05
  • [Presentation] ハイドロゲル人工軟骨/人工骨複合体の可動関節内での安定性評価2016

    • Author(s)
      小俣誠二, 佐々木沙織, 中嶋和弘, 牛尾哲郎, 後藤徳雄, 村上剛史, 桑島海人, 岡崎 賢, 鎗光清道, 松田秀一, 岩本幸英, 村上輝夫
    • Organizer
      2016年 日本生体医工学会九州支部学術講演会
    • Place of Presentation
      佐賀大学(佐賀県佐賀市)
    • Year and Date
      2016-03-05
  • [Presentation] Directional freezing of water for multiscale structures of poly(vinyl alcohol) hydrogels2016

    • Author(s)
      A. Suzuki, S. Nakamura, S. Sasaki, T. Murakami
    • Organizer
      Second International Symposium on Advanced Water Science and Technology (ISAWST-2)
    • Place of Presentation
      Environmental Studies Hall, 名古屋大学(愛知県名古屋市)
    • Year and Date
      2016-02-16
    • Int'l Joint Research / Invited
  • [Presentation] Trends and future perspectives of knee replacementge2016

    • Author(s)
      Ken Okazaki, Hideki Mizuuchi, Satoshi Hamai, Yukio Akasaki, Yukihide Iwamoto
    • Organizer
      International Symposium on Artificial Hydrogel Cartilage, Joint Replacement and Related Topics
    • Place of Presentation
      九州大学伊都ゲストハウス(福岡県福岡市)
    • Year and Date
      2016-01-26
    • Int'l Joint Research
  • [Presentation] Biphasic lubrication of articular cartilage and its application to artificial cartilage2016

    • Author(s)
      Nobuo Sakai, Chie Hashimoto, Seido Yarimitsu, Yoshinori Sawae, Mochimitsu Komori, Teruo Murakami
    • Organizer
      International Symposium on Artificial Hydrogel Cartilage, Joint Replacement and Related Topics
    • Place of Presentation
      九州大学伊都ゲストハウス(福岡県福岡市)
    • Year and Date
      2016-01-26
    • Int'l Joint Research
  • [Presentation] Development of hydrogel artificial cartilage materials with low friction and minimum wear2016

    • Author(s)
      Seido Yarimitsu, Ayumi Yoshida, Saori Sasaki, Teruo Murakami, Atsushi Suzuki
    • Organizer
      International Symposium on Artificial Hydrogel Cartilage, Joint Replacement and Related Topics
    • Place of Presentation
      九州大学伊都ゲストハウス(福岡県福岡市)
    • Year and Date
      2016-01-26
    • Int'l Joint Research
  • [Presentation] Improvement of frictional properties of physically cross-linked PVA hydrogels as artificial cartilage2016

    • Author(s)
      Saori Sasaki, Teruo Murakami, Atsushi Suzuki
    • Organizer
      International Symposium on Artificial Hydrogel Cartilage, Joint Replacement and Related Topics
    • Place of Presentation
      九州大学伊都ゲストハウス(福岡県福岡市)
    • Year and Date
      2016-01-26
    • Int'l Joint Research
  • [Presentation] Flow behavior between cartilage models under compressive load2016

    • Author(s)
      Terukazu Akiyama, Renshi Sawada
    • Organizer
      International Symposium on Artificial Hydrogel Cartilage, Joint Replacement and Related Topics
    • Place of Presentation
      九州大学伊都ゲストハウス(福岡県福岡市)
    • Year and Date
      2016-01-26
    • Int'l Joint Research
  • [Presentation] Friction characterization of hydrogel acetabular liner for hip joint prosthesis2016

    • Author(s)
      Yoshinori Sawae, Ryosuke Baba, Takehiro Morita, Tetsuo Yamaguchi, Martin Vrbka, Filip Urban, David Nečas, Seido Yarimitsu, Kazuhiro Nakashima, Teruo Murakami, Martin Hartl
    • Organizer
      International Symposium on Artificial Hydrogel Cartilage, Joint Replacement and Related Topics
    • Place of Presentation
      九州大学伊都ゲストハウス(福岡県福岡市)
    • Year and Date
      2016-01-26
    • Int'l Joint Research
  • [Presentation] Fatigue and wear of hydrogels2016

    • Author(s)
      Tetsuo Yamaguchi, Ryuichiro Sato, Yoshinori Sawae, Teruo Murakami
    • Organizer
      International Symposium on Artificial Hydrogel Cartilage, Joint Replacement and Related Topics
    • Place of Presentation
      九州大学伊都ゲストハウス(福岡県福岡市)
    • Year and Date
      2016-01-26
    • Int'l Joint Research
  • [Presentation] Assessment of macrophage immune response on wear particles of PVA hydrogel2016

    • Author(s)
      Seiji Omata, Yoshinori Sawae, Teruo Murakami
    • Organizer
      International Symposium on Artificial Hydrogel Cartilage, Joint Replacement and Related Topics
    • Place of Presentation
      九州大学伊都ゲストハウス(福岡県福岡市)
    • Year and Date
      2016-01-26
    • Int'l Joint Research
  • [Presentation] Formation process and characteristic of protein film on joint prosthesis material2016

    • Author(s)
      Kazuhiro Nakashima, Yoshinori Sawae, Susumu Kudo, Teruo Murakami
    • Organizer
      International Symposium on Artificial Hydrogel Cartilage, Joint Replacement and Related Topics
    • Place of Presentation
      九州大学伊都ゲストハウス(福岡県福岡市)
    • Year and Date
      2016-01-26
    • Int'l Joint Research
  • [Presentation] KAKENHI Project : Elucidation of adaptive lubrication mechanism with lowfriction and minimum wear in natural synovial joints and development of artificial hydrogel cartilage with super lubricity based on bionic design2016

    • Author(s)
      Teruo Murakami
    • Organizer
      International Symposium on Artificial Hydrogel Cartilage, Joint Replacement and Related Topics
    • Place of Presentation
      九州大学伊都ゲストハウス(福岡県福岡市)
    • Year and Date
      2016-01-25
    • Int'l Joint Research
  • [Presentation] Computer simulation in total knee arthroplastyge2016

    • Author(s)
      Shuichi Matsuda, Shinichi Kuriyama, Ken Okazaki
    • Organizer
      International Symposium on Artificial Hydrogel Cartilage, Joint Replacement and Related Topics
    • Place of Presentation
      九州大学伊都ゲストハウス(福岡県福岡市)
    • Year and Date
      2016-01-25
    • Int'l Joint Research
  • [Presentation] 繊維強化PVAハイドロゲルの機能向上に関する研究2016

    • Author(s)
      坂井伸朗, 橋本知依, 鎗光清道, 澤江義則, 小森望充, 村上輝夫
    • Organizer
      第28回バイオエンジニアリング講演会
    • Place of Presentation
      東京工業大学(東京都目黒区)
    • Year and Date
      2016-01-09
  • [Presentation] ハイドロゲル人工軟骨候補材料の低摩擦・低摩耗化2016

    • Author(s)
      鎗光清道, 吉田歩, 佐々木沙織, 村上輝夫, 鈴木淳史
    • Organizer
      第28回バイオエンジニアリング講演会
    • Place of Presentation
      東京工業大学(東京都目黒区)
    • Year and Date
      2016-01-09
  • [Presentation] 人工軟骨用ハイドロゲルのトライボ特性および力学特性の評価2016

    • Author(s)
      村上輝夫, 鎗光清道, 中嶋和弘, 山口哲生, 小俣誠二, 佐々木沙織, 澤江義則, 坂井伸朗, 鈴木淳史
    • Organizer
      第28回バイオエンジニアリング講演会
    • Place of Presentation
      東京工業大学(東京都目黒区)
    • Year and Date
      2016-01-09
  • [Presentation] 筋骨格型ヒト歩行シミュレータの開発2016

    • Author(s)
      松井政憲, 坂井伸朗, 小森望充, 村上輝夫
    • Organizer
      第28回バイオエンジニアリング講演会
    • Place of Presentation
      東京工業大学(東京都目黒区)
    • Year and Date
      2016-01-09
  • [Presentation] Development of Artificial Hydrogel Cartilage with Superior Lubricity Based on Bionic Design2015

    • Author(s)
      Teruo Murakami, Seido Yarimitsu, Kazuhiro Nakashima, Nobuo Sakai, Tetsuo Yamaguchi, Seiji Omata, Saori Sasaki, Yoshinori Sawae and Atsushi Suzuki
    • Organizer
      International Conference on Bioelectronics, Biosensors, BioMedical Devices, BioMEMS/NEMS and Applications 2015
    • Place of Presentation
      九州大学椎木講堂(福岡県福岡市)
    • Year and Date
      2015-12-10
    • Int'l Joint Research
  • [Presentation] The musculoskeletal walking simulator2015

    • Author(s)
      Nobuo Sakai, Masanori Matsui, Ryo Fujii, Mochimitsu Komori and Teruo Murakami
    • Organizer
      International Conference on Bioelectronics, Biosensors, BioMedical Devices, BioMEMS/NEMS and Applications 2015
    • Place of Presentation
      九州大学椎木講堂(福岡県福岡市)
    • Year and Date
      2015-12-10
    • Int'l Joint Research
  • [Presentation] Optimum Conditions for Preparation of Anisotropically Strengthened Poly (vinyl alcohol) Gels2015

    • Author(s)
      Atsushi Suzuki, Shun Nakamura, Saori Sasaki, Seido Yarimitsu, and Teruo Murakam
    • Organizer
      International Conference on Bioelectronics, Biosensors, BioMedical Devices, BioMEMS/NEMS and Applications 2015
    • Place of Presentation
      九州大学椎木講堂(福岡県福岡市)
    • Year and Date
      2015-12-10
    • Int'l Joint Research / Invited
  • [Presentation] Peel Force of Physically Crosslinked Poly (vinyl alcohol) Gels Adhered to Porous Medium2015

    • Author(s)
      Shun Nakamura and Atsushi Suzuki
    • Organizer
      International Conference on Bioelectronics, Biosensors, BioMedical Devices, BioMEMS/NEMS and Applications 2015
    • Place of Presentation
      九州大学椎木講堂(福岡県福岡市)
    • Year and Date
      2015-12-10
    • Int'l Joint Research
  • [Presentation] Propagation of fatigue cracks in sliding friction of brittle hydrogels2015

    • Author(s)
      Ryuichiro Sato, Tetsuo Yamaguchi, Takehiro Morita and Yoshinori Sawae
    • Organizer
      International Conference on Bioelectronics, Biosensors, BioMedical Devices, BioMEMS/NEMS and Applications 2015
    • Place of Presentation
      九州大学椎木講堂(福岡県福岡市)
    • Year and Date
      2015-12-10
    • Int'l Joint Research
  • [Presentation] Lubrication property of hydrogel artificial cartilage for hemiarthroplasty2015

    • Author(s)
      S. Yarimitsu, A. Yoshida, S. Sasaki, T. Murakami, A. Suzuki
    • Organizer
      International Conference on Bioelectronics, Biosensors, BioMedical Devices, BioMEMS/NEMS and Applications 2015
    • Place of Presentation
      九州大学椎木講堂(福岡県福岡市)
    • Year and Date
      2015-12-09
    • Int'l Joint Research
  • [Presentation] Relationship of wear amount of poly(vinyl alcohol) (PVA) hydrogel and elution of PVA molecules in lubricant2015

    • Author(s)
      Seiji Omata, Yoshinori Sawae, Teruo Murakami
    • Organizer
      International Conference on Bioelectronics, Biosensors, BioMedical Devices, BioMEMS/NEMS and Applications 2015
    • Place of Presentation
      九州大学椎木講堂(福岡県福岡市)
    • Year and Date
      2015-12-09
    • Int'l Joint Research
  • [Presentation] Effect of lubricant on frictional properties of PVA hydrogels as artificial cartilage2015

    • Author(s)
      Saori Sasaki, Teruo Murakami, Atsushi Suzuki
    • Organizer
      International Conference on Bioelectronics, Biosensors, BioMedical Devices, BioMEMS/NEMS and Applications 2015
    • Place of Presentation
      九州大学椎木講堂(福岡県福岡市)
    • Year and Date
      2015-12-09
    • Int'l Joint Research
  • [Presentation] Analysis of biphasic lubrication of articular cartilage and artificial cartilage2015

    • Author(s)
      Nobuo SAKAI, Chie HASHIMOTO, Seido YARIMITSU, Yoshinori SAWAE, Mochimitsu KOMORI and Teruo MURAKAMI
    • Organizer
      日本機械学会バイオエンジニアリング部門生体システム技術研究会第30回研究会
    • Place of Presentation
      九州大学(福岡県福岡市)
    • Year and Date
      2015-12-07
    • Invited
  • [Presentation] A functional effect of the superficial mechanical properties of articular cartilage as a load bearing system in a migrating contact condition2015

    • Author(s)
      Nobuo Sakai, Chie Hashimoto, Seido Yarimitsu, Yoshinori Sawae, Mochimitsu Komori, Teruo Murakami
    • Organizer
      UPM-Kyutech Collaborative Meeting, The 3rd International Symposium on Applied Engineering and Science
    • Place of Presentation
      マレーシアプトラ大学(カンセロリ プトラ、マレーシア)
    • Year and Date
      2015-11-23 – 2015-11-24
    • Int'l Joint Research
  • [Presentation] 生体軟骨を摩擦相手面としたハイドロゲル人工軟骨の潤滑性評価2015

    • Author(s)
      鎗光清道, 吉田歩, 佐々木沙織, 村上輝夫, 鈴木淳史
    • Organizer
      第42回日本臨床バイオメカニクス学会
    • Place of Presentation
      ソラシティカンファレンスセンター(東京都文京区)
    • Year and Date
      2015-11-13
  • [Presentation] 人工軟骨候補材料としての繊維強化PVAハイドロゲルの固液二相性モデルによる解析2015

    • Author(s)
      坂井伸朗, 橋本知依, 鎗光清道, 澤江義則, 小森望充, 村上輝夫
    • Organizer
      第42回日本臨床バイオメカニクス学会
    • Place of Presentation
      ソラシティカンファレンスセンター(東京都文京区)
    • Year and Date
      2015-11-13
  • [Presentation] 水潤滑液中に溶出したポリビニルアルコール(PVA)分子がPVA水和ゲルの摩耗に与える影響2015

    • Author(s)
      小俣誠二, 澤江義則, 村上輝夫
    • Organizer
      第42回日本臨床バイオメカニクス学会
    • Place of Presentation
      ソラシティカンファレンスセンター(東京都文京区)
    • Year and Date
      2015-11-13
  • [Presentation] 人工関節材料に吸着した蛋白質膜のせん断強さ評価2015

    • Author(s)
      中嶋和弘, 澤江義則, 工藤奨, 村上輝夫
    • Organizer
      第42回日本臨床バイオメカニクス学会
    • Place of Presentation
      ソラシティカンファレンスセンター(東京都文京区)
    • Year and Date
      2015-11-13
  • [Presentation] 整形外科におけるバイオマテリアルの応用2015

    • Author(s)
      松田秀一
    • Organizer
      第37回日本バイオマテリアル学会
    • Place of Presentation
      京都テルサ(京都府京都市)
    • Year and Date
      2015-11-09
    • Invited
  • [Presentation] 人工膝関節置換術におけるバイオメカニクス2015

    • Author(s)
      松田秀一
    • Organizer
      第30回日本整形外科学会基礎学会
    • Place of Presentation
      富山国際会議場(富山県富山市)
    • Year and Date
      2015-10-23
    • Invited
  • [Presentation] Superior lubrication ability and minimal wear of poly (vinyl alcohol) hybrid hydrogel as a novel material application for artificial cartilage2015

    • Author(s)
      Teruo Murakami, Seido Yarimitsu, Kazuhiro Nakashima, Nobuo Sakai, Tetsuo Yamaguchi, Yoshinori Sawae, Atsushi Suzuki
    • Organizer
      2015 ISTA (International Society for Technology in Arthroplasty) Annual Congress
    • Place of Presentation
      ヒルトン ウィーン(オーストリア、ウィーン)
    • Year and Date
      2015-10-02
    • Int'l Joint Research
  • [Presentation] Kinematically aligned TKA increases medial contact forces in the varus deformed knee.2015

    • Author(s)
      Matsuda S
    • Organizer
      The 2015 Knee Society Members Meeting
    • Place of Presentation
      リッツカールトンホテル(アメリカ合衆国、サンフランシスコ)
    • Year and Date
      2015-09-22
    • Int'l Joint Research / Invited
  • [Presentation] Behavior of Protein Film Adsorbed on Joint Prosthesis Material under Rubbing2015

    • Author(s)
      Nakashima K, Sawae Y, Kudo S, Murakami T
    • Organizer
      The 8th International Biotribology Forum
    • Place of Presentation
      横浜シンポジア(神奈川県横浜市)
    • Year and Date
      2015-09-22
    • Int'l Joint Research
  • [Presentation] Synergistic Lubricating Function with Different Modes for Artificial Hydrogel Cartilage2015

    • Author(s)
      Teruo Murakami, Seido Yarimitsu, Kazuhiro Nakashima, Nobuo Sakai, Tetsuo Yamaguchi, Yoshinori Sawae, and Atsushi Suzuki
    • Organizer
      8th International Biotribology Forum
    • Place of Presentation
      横浜シンポジア(神奈川県横浜市)
    • Year and Date
      2015-09-21
    • Int'l Joint Research / Invited
  • [Presentation] Evaluation of lubrication Properties of Hydrogel Artificial Cartilage Materials for Joint Prosthesis2015

    • Author(s)
      S. Yarimitsu, A. Yoshida, K. Nakashima, T. Murakami, S. Sasaki, A. Suzuki
    • Organizer
      8th International Biotribology Forum
    • Place of Presentation
      横浜シンポジア(神奈川県横浜市)
    • Year and Date
      2015-09-21
    • Int'l Joint Research
  • [Presentation] Frictional properties of physically cross-linked PVA hydrogels as artificial cartilage2015

    • Author(s)
      Saori Sasaki, Teruo Murakami, Atsushi Suzuki
    • Organizer
      The 8th International Biotribology Forum
    • Place of Presentation
      横浜シンポジア(神奈川県横浜市)
    • Year and Date
      2015-09-21
    • Int'l Joint Research
  • [Presentation] A functional effect of the superficial mechanical properties of articular cartilage as a load bearing system2015

    • Author(s)
      N. Sakai, C. Hashimoto, S. Yarimitsu, Y. Sawae, M. Komori, T. Murakami
    • Organizer
      The 8th International Biotribology Forum
    • Place of Presentation
      横浜シンポジア(神奈川県横浜市)
    • Year and Date
      2015-09-21
    • Int'l Joint Research
  • [Presentation] Effect of High Gamma-Ray Irradiation Dose on Oxidation and Wear of Cross-Linked Polyethylene2015

    • Author(s)
      L. Zhang, Y. Sawae, T. Yamaguchi and T. Murakami
    • Organizer
      ITC 2015 Tokyo
    • Place of Presentation
      東京理科大学(東京都葛飾区)
    • Year and Date
      2015-09-20
    • Int'l Joint Research
  • [Presentation] Superior Lubricity of Poly (vinyl alcohol) Hydrogels for Artificial Cartilage Based on Bionic Design2015

    • Author(s)
      Teruo Murakami, Seido Yarimitsu, Kazuhiro Nakashima, Tetsuo Yamaguchi, Yoshinori Sawae, Nobuo Sakai, Atsushi Suzuki
    • Organizer
      ITC 2015 Tokyo
    • Place of Presentation
      東京理科大学(東京都葛飾区)
    • Year and Date
      2015-09-20
    • Int'l Joint Research
  • [Presentation] Evaluation of lubrication property of poly (vinyl alcohol) hybrid gel for artificial articular cartilage2015

    • Author(s)
      S. Yarimitsu, A. Yoshida, S. Sasaki, T. Murakami, A. Suzuki
    • Organizer
      ITC 2015 Tokyo
    • Place of Presentation
      東京理科大学(東京都葛飾区)
    • Year and Date
      2015-09-20
    • Int'l Joint Research
  • [Presentation] Propagation of Fatigue Cracks in Sliding Friction of Brittle Hydrogels2015

    • Author(s)
      Ryuichiro Sato, Tetsuo Yamaguchi, Takehiro Morita, Yoshinori Sawae
    • Organizer
      ITC 2015 Tokyo
    • Place of Presentation
      東京理科大学(東京都葛飾区)
    • Year and Date
      2015-09-20
    • Int'l Joint Research
  • [Presentation] nyestigation of Adsorption and Desorption Behavior of Protein Film on Joint Prosthesis Material under Rubbing Condition2015

    • Author(s)
      K. Nakashima, A. Yoshida, S. Kudo, Y. Sawae and T. Murakami
    • Organizer
      ITC 2015 Tokyo
    • Place of Presentation
      東京理科大学(東京都葛飾区)
    • Year and Date
      2015-09-20
    • Int'l Joint Research
  • [Presentation] Effect of eluted poly (vinyl alcohol) (PVA) molecules in water lubricant on total wear amount of PVA hydrogel2015

    • Author(s)
      Seiji Omata, Yoshinori Sawae, Teruo Murakami
    • Organizer
      8th Asian-Pacific Conference on Biomechanics
    • Place of Presentation
      北海道大学(北海道札幌市)
    • Year and Date
      2015-09-19
    • Int'l Joint Research
  • [Presentation] Influence of elastic recovery of machining surface asperities on the wear of polyethylene tibial insert in virgin knee prosthesis2015

    • Author(s)
      Changhee Cho, Teruo Murakami and Yoshinori Sawae
    • Organizer
      ITC 2015 Tokyo
    • Place of Presentation
      東京理科大学(東京都葛飾区)
    • Year and Date
      2015-09-17
    • Int'l Joint Research
  • [Presentation] 物理架橋PVAハイドロゲルの摩擦・摩耗特性と人工軟骨代替材料としての応用2015

    • Author(s)
      佐々木沙織、村上輝夫、鈴木淳史
    • Organizer
      高分子学会第64回高分子討論会
    • Place of Presentation
      東北大学(宮城県仙台市)
    • Year and Date
      2015-09-16
  • [Presentation] Superior Lubrication Ability of Artificial Hydrogel Cartilage2015

    • Author(s)
      Teruo Murakami, Seido Yarimitsu, Kazuhiro Nakashima, Tetsuo Yamaguchi, Yoshinori Sawae, Nobuo Sakai, Atsushi Suzuki
    • Organizer
      27th European Conference on Biomaterials
    • Place of Presentation
      ICE コングレスセンター(ポーランド、クラコフ)
    • Year and Date
      2015-09-01
    • Int'l Joint Research
  • [Presentation] 摩擦環境下で形成される蛋白質吸着膜の形成過程2015

    • Author(s)
      中嶋和弘, 澤江義則, 工藤奨, 村上輝夫
    • Organizer
      第51回九大生体材料・力学研究会
    • Place of Presentation
      九州大学西新プラザ(福岡県福岡市)
    • Year and Date
      2015-07-28
  • [Presentation] 積層PVAキャストドライゲルの摩擦特性評価2015

    • Author(s)
      佐々木沙織、村上輝夫、鈴木淳史
    • Organizer
      第51回九大生体材料・力学研究会
    • Place of Presentation
      九州大学西新プラザ(福岡県福岡市)
    • Year and Date
      2015-07-28
  • [Presentation] Computer Navigation : Is there still a role?2015

    • Author(s)
      Matsuda S
    • Organizer
      2015 2ND ANNUAL PAN PACIFIC ORTHOPAEDIC CONGRESS
    • Place of Presentation
      ヒルトン ワイクロアビレッジ(アメリカ合衆国、コナ)
    • Year and Date
      2015-07-26
    • Int'l Joint Research / Invited
  • [Presentation] ヒトの生理的・能動的下肢運動を再現したシミュレータによる人工膝関節のキネティックス・キネマティックスの測定・評価2015

    • Author(s)
      廣川俊二、木口量夫、官夢茜、村上輝夫、福永道彦
    • Organizer
      第24回バイオメカニズム・シンポジウム
    • Place of Presentation
      岩室温泉ゆもとや(新潟県新潟市)
    • Year and Date
      2015-07-25
  • [Presentation] How intraoperative condition affects postoperative kinematics for Japanese2015

    • Author(s)
      Matsuda S
    • Organizer
      2015 2ND ANNUAL PAN PACIFIC ORTHOPAEDIC CONGRESS
    • Place of Presentation
      ヒルトン ワイクロアビレッジ(アメリカ合衆国、コナ)
    • Year and Date
      2015-07-24
    • Int'l Joint Research / Invited
  • [Presentation] ゲルトは何か?-刺激応答機能について2015

    • Author(s)
      鈴木淳史
    • Organizer
      第146回ポバール会
    • Place of Presentation
      京都大学楽友会館(京都府京都市)
    • Year and Date
      2015-07-04
    • Invited
  • [Presentation] Evaluation of friction and wear properties of poly (vinyl alcohol) hydrogels as artificial articular cartilage2015

    • Author(s)
      S. Yarimitsu, A. Yoshida, K. Nakashima, T. Murakami, S. Sasaki, A. Suzuki
    • Organizer
      Summer Biomechanics, Bioengineering, and Biotransport Conference 2015
    • Place of Presentation
      スノーバードリゾート(アメリカ合衆国, ユタ州)
    • Year and Date
      2015-06-18
    • Int'l Joint Research
  • [Presentation] Relationship of Wear Particles of Poly (vinyl Alcohol) Hydrogel and Immune Response of Macrophage2015

    • Author(s)
      Seiji Omata, Yoshinori Sawae, Teruo Murakami
    • Organizer
      Summer Biomechanics, Bioengineering, and Biotransport Conference 2015
    • Place of Presentation
      スノーバードリゾート(アメリカ合衆国, ユタ州)
    • Year and Date
      2015-06-18
    • Int'l Joint Research
  • [Presentation] Overview of Treatment for Patellofemoral Osteoarthritis.2015

    • Author(s)
      Matsuda S
    • Organizer
      10th Biennial ISAKOS Congress
    • Place of Presentation
      リヨン コンベンションセンター(フランス、リヨン)
    • Year and Date
      2015-06-13
    • Int'l Joint Research / Invited
  • [Presentation] Timing of ACL Surgery : Cons for Early Surgery.2015

    • Author(s)
      Matsuda S
    • Organizer
      10th Biennial ISAKOS Congress (Precourse)
    • Place of Presentation
      リヨン コンベンションセンター(フランス、リヨン)
    • Year and Date
      2015-06-06
    • Int'l Joint Research / Invited
  • [Presentation] ハイドロゲル人工軟骨における潤滑モードの連携2015

    • Author(s)
      村上輝夫、鎗光清道、中嶋和弘、坂井伸朗、山口哲生、澤江義則、鈴木淳史
    • Organizer
      トライボロジー会議 2015春 姫路
    • Place of Presentation
      姫路商工会議所(兵庫県姫路市)
    • Year and Date
      2015-05-29
  • [Presentation] 人工関節材料の摩擦摩耗特性へ影響する蛋白質吸着膜の観察2015

    • Author(s)
      中嶋和弘、澤江義則、工藤 奨、村上輝夫
    • Organizer
      トライボロジー会議 2015春 姫路
    • Place of Presentation
      姫路商工会議所(兵庫県姫路市)
    • Year and Date
      2015-05-29
  • [Presentation] 人工膝関節置換術における適切な靭帯バランスとは2015

    • Author(s)
      松田秀一
    • Organizer
      第88回日本整形外科学会学術総会
    • Place of Presentation
      神戸ポートピアホテル(兵庫県神戸市)
    • Year and Date
      2015-05-22
    • Invited
  • [Presentation] ワイヤ駆動型下肢シミュレータの屈曲伸展運動の制御2015

    • Author(s)
      官夢茜、木口量夫、廣川俊二、村上輝夫、福永道彦
    • Organizer
      ROBOMECH2015 京都
    • Place of Presentation
      京都市勧業館みやこめっせ(京都府京都市)
    • Year and Date
      2015-05-09
  • [Presentation] 人工軟骨候補材料の固液二相性潤滑特性の解析2015

    • Author(s)
      橋本知依, 坂井伸朗, 内村智章, 鎗光清道, 小森望充, 澤江義則, 村上輝夫
    • Organizer
      第54回 日本生体医工学会大会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2015-05-09
  • [Presentation] No Lift-off Motion Occurs with Proper Coronal Alignment Regardless of Lateral Laxity in TKA.2015

    • Author(s)
      Matsuda S
    • Organizer
      2015 World Arthroplasty Congress
    • Place of Presentation
      Palais Congres (フランス、パリ)
    • Year and Date
      2015-04-15
    • Int'l Joint Research / Invited
  • [Book] Encyclopedia of Biocolloid and Biointerface Science, Chapter on High-strength poly (vinyl alcohol) hydrogels for artificial cartilage2016

    • Author(s)
      A. Suzuki and T. Murakami
    • Publisher
      Wiley
  • [Book] Encyclopedia of Biocolloid and Biointerface Science, Chapter on Superior Tribological Behaviors of Articular Cartilage and Artificial Hydrogel Cartilage,2016

    • Author(s)
      T. Murakami and A. Suzuki
    • Publisher
      Wiley
  • [Book] Rheology of Bio-related Soft Matter, Chapt. 16. Development of PVA Gels with Superior Lubricity for Artificial Cartilage2016

    • Author(s)
      A. Suzuki, S. Sasaki and T. Murakami
    • Publisher
      Springer
  • [Remarks]

    • URL

      http://bio.mech.kyushu-u.ac.jp/spr/index.html

  • [Funded Workshop] International Symposium on Artificial Hydrogel Cartilage, Joint Replacement and Related Topics2016

    • Place of Presentation
      九州大学伊都ゲストハウス(福岡県福岡市)
    • Year and Date
      2016-01-25 – 2016-01-26

URL: 

Published: 2017-03-16  

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