2015 Fiscal Year Final Research Report
Study of bacterial stratagem to circumvent host innate immune system and its application.
| Project/Area Number |
23000012
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| Research Category |
Grant-in-Aid for Specially Promoted Research
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2011 – 2015
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| Keywords | 自然免疫 / 赤痢菌 / エフェクター / 感染モデル / インフラマソーム |
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| Outline of Final Research Achievements |
The intestinal epithelium equips multiple layers of innate defense system and acts as defensive barriers against microbial invaders. Nevertheless, many mucosal pathogenic bacteria can circumvent these defenses and exploit the intestinal epithelium as a replicative niche, a shelter from the host immune surveillance, or a port of entry for dissemination into deeper tissues. In this project, we have concentrated our efforts to (1) Elucidate how Shigella modulate host innate immune response and define the bacterial and host targeting factors, (2) Construct mice intestinal infection model of Shigella, (3) Isolate small compounds that inhabit Shigella effectors.
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| Free Research Field |
医歯薬学
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