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2015 Fiscal Year Final Research Report

Molecular and cellular mechanisms underlying memory update system

Research Project

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Project/Area Number 23220009
Research Category

Grant-in-Aid for Scientific Research (S)

Allocation TypeSingle-year Grants
Research Field Neuroscience in general
Research InstitutionUniversity of Toyama

Principal Investigator

Inokuchi Kaoru  富山大学, 大学院医学薬学研究部(医学), 教授 (20318827)

Co-Investigator(Kenkyū-buntansha) OKADA Daisuke  北里大学, 医学部, 准教授 (10211806)
Co-Investigator(Renkei-kenkyūsha) OHKAWA Noriaki  富山大学, 大学院医学薬学研究部(医学), 講師 (80416651)
SUZUKI Akinobu  富山大学, 大学院医学薬学研究部(医学), 助教 (40424684)
Shehata Mohammad  富山大学, 大学院医学薬学研究部(医学), 助教 (60444197)
SUZUKI Reiko  富山大学, 大学院医学薬学研究部(医学), 特命助教 (50532404)
NISOZONO Hirofumi  富山大学, 研究推進機構研究推進総合支援センター, 助教 (10502289)
Research Collaborator NOMOTO Masanori  
YOKOSE Jun  
MURAYAMA Emi  
ZHAO Qi  
KITAMURA Takashi  
Project Period (FY) 2011-04-01 – 2016-03-31
Keywords記憶アップデート / 神経科学 / セルアセンブリ / 連合記憶 / 光遺伝学 / 海馬 / 扁桃体 / シナプスタグ
Outline of Final Research Achievements

In this study, memory update mechanisms were investigated in cell assembly level. We found that, when two distinct units of information interact to generate a new memory, cellular ensembles corresponding to individual memories overlap. Suppressing the overlap neurons inhibits the association between two memories without affecting the initial memories. In addition, optogenetical co-activation of these ensembles creates an artificial memory. These results indicate that overlap in cellular ensembles plays a critical role in memory association.

Free Research Field

脳科学

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Published: 2017-05-10  

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