2015 Fiscal Year Final Research Report
Rapid Synthesis of Complex Molecules Using Super Bronsted Acid Catalysis
| Project/Area Number |
23225002
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| Research Category |
Grant-in-Aid for Scientific Research (S)
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| Allocation Type | Single-year Grants |
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| Research Field |
Synthetic chemistry
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| Research Institution | Chubu University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Keywords | ポリケチド / スーパーシリル / ブレンステッド酸 / ルイス酸 / ジアステレオ選択的 / 抗生物質 / 糖 / フローシステム |
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| Outline of Final Research Achievements |
Modern drugs and agrochemicals are highly functionalized molecules. These molecules are synthesized in multi-steps and frequently without any desired selectivity. For example, polyketide frameworks are prepared in a number of steps and it is almost impossible to prepared only one desired molecule among hundreds of isomers. In this project, we have developed the exceedingly bulky silyl reagent to prepare such polyketides with almost exclusive stereoselectivity. Further, the method was used to prepare biologically active antibiotics as well as sugar derivatives in short steps.
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| Free Research Field |
有機化学
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