Elucidation of aging regulatory mechanisms related to mitochondrial function and identification of anti-aging food factors

2015 Fiscal Year Final Research Report

• Project/Area Number: 23228003
• Research Category: Grant-in-Aid for Scientific Research (S)
• Allocation Type: Single-year Grants
• Research Field: Food science
• Research Institution: The University of Tokyo
• Principal Investigator: TANOKURA Masaru 東京大学, 農学生命科学研究科, 教授 (60136786)
• Co-Investigator(Kenkyū-buntansha): HACHIMURA Satoshi 東京大学, 大学院農学生命科学研究科, 准教授 (40238019) ; MIYAKAWA Takuya 東京大学, 大学院農学生命科学研究科, 助教 (50596559)
• Research Collaborator: SOMEYA Shinichi
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: 老化 / 抗老化 / ミトコンドリア / 食品 / 食物質

Outline of Final Research Achievements

Reactive oxygen species (ROS), which is produced in mitochondria, induces age-related changes in cell and tissue homeostasis. In the present researches, we analyzed the molecular basis of oxidative-stress regulation, which is one of mitochondrial functions mediated by deacetylase Sirt3, and then revealed downstream targets of Sirt3 and their regulatory mechanisms. In addition, we also revealed a novel mechanism of immunosenescence and that chronic inflammation, which is considered to be a basic pathology of age-related diseases, was facilitated by mitochondrial DNA mutations and aging. The combination of assay systems based on these molecular bases and NMR metabolic profiling was used to identify several food factors that regulate aging signals including Sirt3-dependent antioxidant system and proinflammatory cytokine production.

Free Research Field

食品生物構造学