2014 Fiscal Year Final Research Report
Comprehensive analysis of human brain network structure based on graph theory using brain MRI
| Project/Area Number |
23240056
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Fusional brain recording science
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| Research Institution | Tohoku Pharmaceutical University (2012-2013)
Tohoku University (2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
TAKI Yasuyuki 東北大学, 加齢医学研究所, 教授 (10375115)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Keywords | ヒト脳ネットワーク解析 / 脳発達・加齢 / 形態MRI / 拡散テンソル画像 / 機能的MRI / グラフ理論 / small world |
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| Outline of Final Research Achievements |
The human brain exhibits a complex network and makes information transmission with high efficiency. We performed network analysis based on graph theory using a large scale brain MRI database of healthy Japanese. The results indicated that subjects from children to older age exhibited a “small-world” property in that they are characterized by highly connected hubs and modularity. Structural brain networks in three age groups (young, middle, old) changed developed into a more distributed organization from young to middle age and then altered greatly, shifting into a more localized organization in old age. The modular organization of brain network was similar between the young and middle age groups, but quite different from the older groups. In particular, the old group showed a notable decrease in the connector ratio and the inter-module connection. Our findings provide quantitative insights into topological principles of brain networks and changes related to normal aging.
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| Free Research Field |
画像医学、脳神経科学
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