Studies on pathogeneses of mitochondrial DNA-based disorders

2015 Fiscal Year Final Research Report

• Project/Area Number: 23240058
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Laboratory animal science
• Research Institution: University of Tsukuba
• Principal Investigator: NAKADA Kazuto 筑波大学, 生命環境系, 教授 (80323244)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Keywords: ミトコンドリア / ミトコンドリアDNA / 突然変異 / ミトコンドリア呼吸機能異常 / ミトコンドリア病 / モデルマウス

Outline of Final Research Achievements

The aim of this study was to clear multiple pathogeneses of mitochondrial DNA (mtDNA)-related disorders by using model mice carrying mutant mtDNAs. As results, 1) we succeeded in generating novel model mice carrying mtDNA with a point mutation in tRNA-Lys gene, and the mice expressed myopathy due to the accumulation of mtDNA with a point mutation in tRNA-Lys gene; 2) we showed that mtDNA with a point mutation in ND6 gene was responsible for age-related lymphoma in mice; 3) the diabetic condition was a possible modifier to enhance the pathogenicity of mutant mtDNAs.

Free Research Field

細胞生物学