2014 Fiscal Year Final Research Report
Polymer materials design to engineer assembly and function of biopolymers
| Project/Area Number |
23240074
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Institute of Technology (2013-2014)
Kyushu University (2011-2012) |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Keywords | グラフト共重合体 / 高分子電解質複合体 / 高次構造 / DNA / ペプチド / 自己組織化 / 脂質膜 |
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| Outline of Final Research Achievements |
Proper folding and assembling are key processes for biopolymers to exhibit their inherent biological activities. Artificial materials that can manipulate biopolymer folding and asssemling would have variety of applications in biomedical fields. We have designed ionic graft copolymers consisting of a polyion backbone and hydrophilic graft chains to engineer folding and assembling of biopolymers, such as DNA and peptides, having opposite ionic charges. The cationic copolymers formed soluble inter-polyelectrolyte complex with DNA and acidic peptides and enhanced their functions.
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| Free Research Field |
生体機能性材料
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