2013 Fiscal Year Final Research Report
Development of on-demand multifunctional delivery systems using dendron lipid assemblies
| Project/Area Number |
23240075
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
KENJI Kono 大阪府立大学, 工学(系)研究科(研究院), 教授 (90215187)
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| Co-Investigator(Kenkyū-buntansha) |
AOKI Ichio 放射線医学総合研究所, 分子イメージング研究センター, チームリーダー (10319519)
WATARAI Shinobu 大阪府立大学, 大学院生命環境研究科, 准教授 (10319519)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 薬物伝達システム / ナノ医療 |
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| Research Abstract |
We developed various types of functional dendron-bearing lipids, which include gene delivery dendron lipids, temperature-sensitive dendron lipids, pH-sensitive dendron lipids, and MR imaging dendron lipids. We found that gene delivery dendron lipids achieved highly efficient gene transfection into culture cells through hydrophobic interaction and proton sponge effect. Temperature-dendron lipids were shown to provide a new type of temperature-responsive vesicles that undergo morphology transition at a specific temperature. pH-Sensitive dendron lipids formed highly pH-responsive vesicles with egg yolk phosphatidylcholine that release contents in the endosome of a cell. MR imaging dendron lipids were useful for detection of bio-distribution and accumulation of liposomes, which can lead to personalized chemotherapy. The dendron lipid technology is expected to contribute development of new efficient noninvasive cancer therapy.
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[Journal Article] Multifunctional liposomes having temperature-triggered release and magnetic resonance imaging for tumor-specific chemotherapy2011
Author(s)
K. Kono, S. Nakashima, D. Kokuryo, I.Aoki, H. Shimomoto, S. Aoshima, K. Maruyama, E. Yuba, C. Kojima, A. Harada, Y. Ishizaka
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Journal Title
Biomaterials
Volume: 32
Pages: 1387-1395
Peer Reviewed
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