2013 Fiscal Year Final Research Report
Renal rehabilitation: clarification of mechanism of effectiveness and clinical application
| Project/Area Number |
23240084
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Tohoku University |
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Principal Investigator |
KOHZUKI Masahiro 東北大学, 医学(系)研究科(研究院), 教授 (70234698)
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| Co-Investigator(Kenkyū-buntansha) |
ITO Osamu 東北大学, 大学院医学系研究科, 准教授 (00361072)
MORI Nobuyoshi 東北大学, 大学院医学系研究科, 助教 (50463790)
ITO Sadayoshi 東北大学, 大学院医学系研究科, 教授 (40271613)
SAITO Takao 福岡大学, 医学研究科, 教授 (10125552)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | リハビリテーション / 循環器・高血圧 / 腎臓 / 医療・福祉 / 細胞・組織 |
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| Research Abstract |
Effect of exercise training on renal protection was examined, and mechanism was clarified in rats with renal disease. Clinical benefits of exercise training were examined in hemodialysis patients. In rats with chronic renal failure, a combination therapy with exercise training and angiotensin II receptor blocker had renal protective effects, and an alleviation of carbonyl stress might mediate the renal protective effects. In Dahl salt-sensitive rats, exercise training had renal protective effects with an independent manner of systemic blood pressure, and improvement of oxidative stress and nitric oxide system might mediate the renal protective effects. We developed a low-pried, light weight, work load-controllable bicycle ergometer for exercise training in the hemodialysis period, and recognize beneficial effects of physical functions and QOL in hemodialysis patients.
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[Journal Article] 5/6 腎摘除慢性腎不全モデルラットにおける長期的運動とG-CSF の併用療法による腎保護効果2011
Author(s)
須田千尋, 金澤雅之, 姚 強, 高島健太,坂田佳子, 室谷嘉一, 森 信芳, 長坂誠, 海老原覚, 伊藤 修, 上月正博
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Journal Title
運動療法と物理療法
Volume: 22
Pages: 78-84
Peer Reviewed
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[Presentation] Exercise training increases nitric oxide synthases in the kidney of rats with chronic heart failure2011
Author(s)
Ito D, Ito O, Mori N, Suda C, Hao K, Cao P, Rong R, Muroya Y, Takashima K, Shimokawa H, Kohzuki M
Organizer
65th Annual Fall Conference and Scientific Session of the Council for High Blood Pressure Research
Place of Presentation
Orland, USA
Year and Date
2011-09-22
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[Presentation] Ebihara S, Ito O, Kohzuki M. Combination of chronic exercise and G-CSF protects renal function in chronic renal failure (CRF) rats2011
Author(s)
Suda T, Kanazawa M, Yao Q, Takashima K, Sakata Y, Muroya Y, Mori N, Nagasaka M
Organizer
6th World Congress of the International Society of Physical and Rehabilitation Medicine
Place of Presentation
San Juan, Puerto Rico
Year and Date
2011-06-13
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