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2014 Fiscal Year Final Research Report

Development of novel biomarkers on exercise, stress and aging

Research Project

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Project/Area Number 23240097
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Applied health science
Research InstitutionWaseda University

Principal Investigator

SUZUKI Katsuhiko  早稲田大学, スポーツ科学学術院, 教授 (80344597)

Co-Investigator(Kenkyū-buntansha) AKIMOTO Takayuki  東京大学, 大学院医学系研究科, 講師 (00323460)
Project Period (FY) 2011-04-01 – 2015-03-31
Keywordsバイオマーカー / プロテオミクス / マイクロアレイ / リボソームプロファイリング
Outline of Final Research Achievements

In order to explore new biomarkers which respond to exercise and stress, we performed proteomics using blood and urine samples before and after exhaustive exercise and identified the molecules using mass spectrometric analyses. Among the molecules which exhibited remarkable increases, we developed measurement system using ELISA. Also, we identified several microRNAs in the blood circulation in response to acute resistant exercise using microarray, and quantified expression levels using real-time PCR. Furthermore, we set up global analyses of translation dynamics using ribosome profiling for biomarker discovery.

Free Research Field

予防医学

URL: 

Published: 2016-06-03  

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