Preventive effects of dietary polyphenols in atherosclerosis; a new approach targeting postprandial inflammation

2014 Fiscal Year Final Research Report

• Project/Area Number: 23240104
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Eating habits, studies on eating habits
• Research Institution: Ochanomizu University
• Principal Investigator: KONDO Kazuo お茶の水女子大学, 大学院人間文化創成科学研究科, 教授 (30153711)
• Co-Investigator(Kenkyū-buntansha): IIDA Kaoruko お茶の水女子大学, 大学院人間文化創成科学研究科, 准教授 (50375458)
• Co-Investigator(Renkei-kenkyūsha): TANI Mariko 東京医科歯科大学, 大学院医歯学総合研究科, 寄附研究部門准教授 (90452028) ; KISHIMOTO Yoshimi お茶の水女子大学, お茶大アカデミック・プロダクション, 寄附研究部門准教授 (70600477)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 食後高脂血症 / 食後高血糖 / 動脈硬化 / 血管炎症

Outline of Final Research Achievements

We conducted the human clinical studies to evaluate postprandial inflammatory responses after fat or glucose intake in healthy subjects. The inflammatory responses and the attenuation of endothelium-dependent vasodilation were observed in postprandial state, which were partly improved by co-intake of fruit derived polyphenol. In cultured cell models, we confirmed the anti-inflammatory effects of polyphenols under the stimulation of fatty acid, glucose or LPS. These results suggest that polyphenols may contribute to improve postprandial inflammatory responses leading to atherosclerosis.

Free Research Field

脂質代謝学