2014 Fiscal Year Final Research Report
The role of HB-EGF in cancer cell proliferation and malignancy
Project/Area Number |
23240126
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Tumor biology
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Research Institution | Osaka University |
Principal Investigator |
MEKADA Eisuke 大阪大学, 微生物病研究所, 教授 (20135742)
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Project Period (FY) |
2011-04-01 – 2015-03-31
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Keywords | EGFファミリー / 増殖因子 |
Outline of Final Research Achievements |
We have studied on the role of HB-EGF in cancer cell proliferation and malignancy. In 2011, we have studied the role of HB-EGF expressing at tumor stroma in uterine cervical cancer. We have shown that HB-EGF expressed in stroma and PDGF expressed in cancer cells contribute to the reciprocal interaction of cancer cells with cancer-associated fibroblasts and promote cancer cell proliferation in a paracrine manner, providing an insight for the novel combinatorial therapy. In 2012-2013, we have studied on the molecular mechanism of HB-EGF-inducing growth inhibition. In cardiac valve, HB-EGF inhibits the proliferation of mesenchymal cells. The study indicated that HB-EGF is expressed in cardiac epithelial cells and secreted toward the mesenchymal cells in developing heart valve tissue, where HB-EGF inhibits mesenchymal cell proliferation. P38 MAPK and JNK are involved in this process. Further study may provide a new paradigm for cancer therapy.
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Free Research Field |
腫瘍生物学、細胞生物学
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