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2013 Fiscal Year Final Research Report

Higher Speed Biosensing Techniques based on Nano-surgery System

Research Project

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Project/Area Number 23246044
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Intelligent mechanics/Mechanical systems
Research InstitutionMeijo University (2013)
Nagoya University (2011-2012)

Principal Investigator

FUKUDA Toshio  名城大学, 理工学部, 教授 (70156785)

Co-Investigator(Kenkyū-buntansha) NAKAJIMA Masahiro  名古屋大学, 工学研究科, 助教 (80377837)
Project Period (FY) 2011-05-31 – 2014-03-31
Keywordsナノサージェリ / バイオセンシング / マイクロ・ナノデバイス / モデル生物 / マイクロ流体デバイス
Research Abstract

Currently, the bio-sensing technologies have been received much attention for smart, safe, and high-sensitive analysis of environmental materials using living organism directly with some effects on ecosystem. In this research, we applied our nanomanipulation technique to realize single cell level local analysis using various nano-tools. We proposed a bio-indicator device for heavy metal inside some solution by controlling a micro-fluidic chip to use a model organism.

  • Research Products

    (29 results)

All 2014 2013 2012 2011 Other

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (15 results) Remarks (1 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] A microfluidic device with multi valves system to enable simultaneous several exposure tests on Caenorhabditis elegans2014

    • Author(s)
      Jaehoon Jung, Masahiro Nakajima, Masaru Takeuchi, Qiang Huang, Toshio Fukuda
    • Journal Title

      Journal of Micromechanics and Microengineering

      Volume: Vol.24, No.3 Pages: 035012

    • Peer Reviewed
  • [Journal Article] Microfluidic device for the continuous culture and analysis of Caenorhabditis elegans in a toxic aqueous environment2013

    • Author(s)
      Jaehoon Jung, Masahiro Nakajima, Hirotaka Tajima, Toshio Fukuda
    • Journal Title

      Journal of Micromechatronics and Microengineering

      Volume: Vol.23 Pages: 085008, 8

    • Peer Reviewed
  • [Journal Article] Single cell stiffness measurement at various humidity conditions by nanomanipulation of a nano-needle2013

    • Author(s)
      Yajing Shen, Masahiro Nakajima, Zhan Yang, Hirotaka Tajima, Zoran Najdovski, Michio Homma, Toshio Fukuda
    • Journal Title

      Nanotechnology

      Volume: Vol.24, Number 14 Pages: 145703

    • Peer Reviewed
  • [Journal Article] Instantaneous and Quantitative Single Cells Viability Determination Using Dual Nanoprobe Inside ESEM2012

    • Author(s)
      Mohd Ridzuan Ahmad, Masahiro Nakajima, Masaru Kojima, Seiji Kojima, Michio Homma, Toshio Fukuda
    • Journal Title

      IEEE Transactions on Nanotechnology

      Volume: Vol.11, No.2 Pages: 298-306

    • Peer Reviewed
  • [Journal Article] Nanofork for Single Cells Adhesion Measurement via ESEM-Nanomanipulator System2012

    • Author(s)
      Mohd Ridzuan Ahmad, Masahiro Nakajima, Masaru Kojima, Seiji Kojima, Michio Homma, Toshio Fukuda
    • Journal Title

      IEEE Transactions on Nanobioscience

      Volume: Vol.11, No.1 Pages: 70-78

    • Peer Reviewed
  • [Journal Article] Microchip device for measurement of body volume of C. elegans as bioindicator application2012

    • Author(s)
      Jaehoon Jung, Masahiro Nakajima, Masaru Kojima, Katsutoshi Ooe, Toshio Fukuda
    • Journal Title

      Journal of Micro - Nano Mechatronics

      Volume: Vol.7 Pages: 3-11

    • Peer Reviewed
  • [Journal Article] Evaluation of the single yeast cell's adhesion to ITO substrates with various surface energies via ESEM nanorobotic manipulation system2011

    • Author(s)
      Yajing Shen, Mohd Ridzuan Ahmad, Masahiro Nakajima, Seiji Kojima, Michio Homma, Toshio Fukuda
    • Journal Title

      IEEE Transactions on Nanobioscience

      Volume: Vol.10, No.4 Pages: 217-224

    • Peer Reviewed
  • [Journal Article] Study of the time effect on the strength of cell-cell adhesion force by a novel nano-picker2011

    • Author(s)
      Yajing Shen, Masahiro Nakajima, Seiji Kojima, Michio Homma, Toshio Fukuda
    • Journal Title

      Biochemical and Biophysical Research Communication

      Volume: Vol.409, No.2 Pages: 160-165

    • Peer Reviewed
  • [Journal Article] Single cell adhesion force measurement for cell viability identification by using AFM cantilever based micro putter2011

    • Author(s)
      Yajing Shen, Masahiro Nakajima, Seiji Kojima, Michio Homma, Masaru Kojima, Toshio Fukuda
    • Journal Title

      Measurement science and technology

      Volume: Vol.22, No.11 Pages: 115802

    • Peer Reviewed
  • [Journal Article] Design and characterization of nanoknife with buffering beam for in situ single cell cutting2011

    • Author(s)
      Yajing Shen, Masahiro Nakajima, Zhan Yang, Seiji Kojima, Michio Homma, Toshio Fukuda
    • Journal Title

      Nanotechnology

      Volume: Vol.22, No.30 Pages: 305701

    • Peer Reviewed
  • [Journal Article] Effect of ambient humidity on the strength of the adhesion force of single yeast cell inside environmental-SEM2011

    • Author(s)
      Yajing Shen, Masahiro Nakajima, Mohd Ridzuan Ahmad, Seiji Kojima, Michio Homma, Toshio Fukuda
    • Journal Title

      Ultramicroscopy

      Volume: Vol.111, No.8 Pages: 1176-1183

    • Peer Reviewed
  • [Journal Article] Buckling Nanoneedle for Characterizing Single Cells Mechanics inside Environmental SEM2011

    • Author(s)
      Mohd Ridzuan Ahmad, Masahiro Nakajima, Seiji Kojima, Michio Homma, Toshio Fukuda
    • Journal Title

      IEEE Transactions on Nanotechnology

      Volume: Vol.10 Issue 2 Pages: 226-236

    • Peer Reviewed
  • [Presentation] Microfluidic device for Coincident Multi-exposure test on C. elegans2013

    • Author(s)
      Jahoon Jung, Masahiro Nakajima, Masaru Takeuchi, Qiang Huang, Toshio Fukuda
    • Organizer
      Proceedings 2013 International Symposium on Micromechatronics and Human Science
    • Place of Presentation
      (60-63, 査読有)
    • Year and Date
      20130000
  • [Presentation] Real-Time Measurement of the Adhesion Force by Hybrid System of ESEM and AFM Cantilever2013

    • Author(s)
      Yajing Shen, Masahiro Nakajima, Zhan Yang, Qiang Huang, Toshio Fukuda
    • Organizer
      Proceedings 13th IEEE International Conference on Nanotechnology(IEEE-Nano 2013)
    • Place of Presentation
      (325-328, 査読有)
    • Year and Date
      20130000
  • [Presentation] Micro Fluidic Device to Analyze the Effect of Cadmium on Caenorhabditis elegans2012

    • Author(s)
      Jaehoon Jung, Masahiro Nakajima, Hirotaka Tajima, Toshio Fukuda
    • Organizer
      Proceedings of the 2012 International Symposium on Micromechatronics and Human Science (MHS 2012)
    • Place of Presentation
      (262-267, 査読有)
    • Year and Date
      20120000
  • [Presentation] Auto Nanomanipulation System for Single Cell Mechanical Property Characterization inside an Environmental SEM2012

    • Author(s)
      Yajing Shen, Masahiro Nakajima, Masaru Kojima, Toshio Fukuda
    • Organizer
      Proceedings of the 2012 IEEE/RSJ International Conference on Intelligent Robotics and Systems (IROS 2012)
    • Place of Presentation
      (646-651, 査読有)
    • Year and Date
      20120000
  • [Presentation] Micro Fluidic Device to Control the Position and to Analyze the Condition of C. elegans as a Bioindicator2012

    • Author(s)
      Jaehoon Jung, Masahiro Nakajima, Masaru Kojima, Hirotaka Tajima, Toshio Fukuda
    • Organizer
      Proceedings of the 2012 IEEE/RSJ International Conference on Intelligent Robotics and Systems (IROS 2012)
    • Place of Presentation
      (932-937, 査読有)
    • Year and Date
      20120000
  • [Presentation] Nano Needle with Buffering Beam for Single Cell Stiffness Measurement by Nanorobotic Manipulators inside ESEM2012

    • Author(s)
      Yajing Shen, Masahiro Nakajima, Zhan Yang, Michio Homma, Toshio Fukuda
    • Organizer
      Proceedings of the 2012 12th IEEE Conference on Nanotechnology (IEEE-Nano 2012)
    • Place of Presentation
      (4 pages, 1-4, 査読有)
    • Year and Date
      20120000
  • [Presentation] Development of the Auto Manipulation System towards the Single Cell Automatic Analysis inside an Environmental SEM2012

    • Author(s)
      Yajing Shen, Masahiro Nakajima, TaoYue, Seiji Kojima, Michio Homma, Toshio Fukuda
    • Organizer
      Proceedings of the 2012 IEEE International Conference on Robotics and Automation (ICRA 2012)
    • Place of Presentation
      (4594-4599, 査読有)
    • Year and Date
      20120000
  • [Presentation] Selective Nano-injection using Nano-Probe based on Nanomanipulation under Hybrid Microscope2011

    • Author(s)
      Takahiro Hirano, Masahiro Nakajima, Masaru Kojima, Naoki Hisamoto, Michio Homma, Toshio Fukuda
    • Organizer
      Proceedings of the 2011 International Symposium on Micromechatronics and Human Science (MHS 2011)
    • Place of Presentation
      (216-221, 査読有)
    • Year and Date
      20110000
  • [Presentation] Method to Study the Single Cell's Time-variation Adhesion Strength during the Manipulation inside ESEM2011

    • Author(s)
      Yajing Shen, Masahiro Nakajima, Zoran Najdovski, Zhan Yang, Masaru Kojima, Seiji Kojima, Michio Homma, Toshio Fukuda
    • Organizer
      Proceedings of the 2011 International Symposium on Micromechatronics and Human Science (MHS 2011)
    • Place of Presentation
      (210-215, 査読有)
    • Year and Date
      20110000
  • [Presentation] Measurement of Body Volume of Live C. elegans by Microchip2011

    • Author(s)
      Jaehoon Jung, Masahiro Nakajima, Masaru Kojima, Toshio Fukuda
    • Organizer
      Proceedings of the 2011 International Symposium on Micromechatronics and Human Science (MHS 2011)
    • Place of Presentation
      (204-209, 査読有)
    • Year and Date
      20110000
  • [Presentation] Microchip Analysis Device for Fixed Caenorhabditis elegans by Tapered Micro channel2011

    • Author(s)
      Jaehoon Jung, Masahiro Nakajima, Masaru Kojima, Toshio Fukuda
    • Organizer
      Proceedings of the SICE Annual Conference 2011
    • Place of Presentation
      (2421-2426, 査読有)
    • Year and Date
      20110000
  • [Presentation] Evaluation of Nano-Knife's Edge Angle for Single Cell Cutting by Using Nanorobotic Manipulators Inside ESEM2011

    • Author(s)
      Yajing Shen, Masahiro Nakajima, Zhang Yang, Seiji Kojima, Michio Homma, Toshio Fukuda, Masaru Kojima
    • Organizer
      Proceedings of the 2011 11th IEEE Conf. on Nanotechnology (IEEE-Nano 2011)
    • Place of Presentation
      (Vol.1, 155-160, 査読有)
    • Year and Date
      20110000
  • [Presentation] Direct Nano-injection Method by Nanoprobe Insertion based on E-SEM Nanorobotic Manipulation under Hybrid Microscope2011

    • Author(s)
      Masahiro Nakajima, Takanori Hirano, Masaru Kojima, Naoki Hisamoto, Michio Homma, Toshio Fukuda
    • Organizer
      Proceedings of the 2011 IEEE International Conference on Robotics and Automation (ICRA 2011)
    • Place of Presentation
      (4139-4144, 査読有)
    • Year and Date
      20110000
  • [Presentation] Characterization of Oscillating Nano Knife for Single Cell Cutting by Nanorobotic Manipulation System inside ESEM2011

    • Author(s)
      Yajing Shen, Masahiro Nakajima, Seiji Kojima, Michio Homma, Toshio Fukuda
    • Organizer
      Proceedings of the 2011 IEEE International Conference on Robotics and Automation (ICRA 2011)
    • Place of Presentation
      (4133-4138, 査読有)
    • Year and Date
      20110000
  • [Presentation] Measurement for Viability Identification using Nanorobotic Manipulation System inside ESEM2011

    • Author(s)
      Yajing Shen, Masahiro Nakajima, Seiji Kojima, Michio Homma, Toshio Fukuda
    • Organizer
      Proceedings of 2011 IEEE International Conference on Nano/Micro Engineered and Molecular Systems (IEEE-NEMS 2011)
    • Place of Presentation
      (944-947, 査読有)
    • Year and Date
      20110000
  • [Remarks]

    • URL

      http://www.mein.nagoya-u.ac.jp/indexj.html

  • [Patent(Industrial Property Rights)] 微生物の電気化学的特性の解析用マイクロチップデバイス2011

    • Inventor(s)
      福田敏男,中島正博,小嶋勝
    • Industrial Property Rights Holder
      福田敏男,中島正博,小嶋勝
    • Industrial Property Number
      特願2011-231134
    • Filing Date
      2011-09-16

URL: 

Published: 2015-06-25  

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