2013 Fiscal Year Final Research Report
| Project/Area Number |
23246069
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Electron device/Electronic equipment
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| Research Institution | Waseda University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | アプタマ / トランジスタ / タンパク質 |
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| Research Abstract |
Specific targets were detected by short DNA and RNA aptamers immobilized on diamond. 1) HIV-TAT protein(target) and platelet derived growth factor (PDGF) were detected by their aptamers using two methods such as photonic method based on fluorescence dye and potentiometric method based on field effect transistor (FET). The bonding between aptamer and their targets were discussed by the two different detecting mechanisms. 2) Adenosine-triphosphate (ATP) has been clearly detected by without-marker on ATP, but with-marker on its aptamer. It shows the possibility of label free aptamer sensor, 3) PDGF were selectively detected by different transistors in FET arrays which are placed at the bottom of micro flow channels. It leads to the basic technology for integrated micro bio-systems.
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[Presentation] Boron-delta-doped Channel Diamond SGFET for Single Mismatched DNA Detection2011
Author(s)
S.Ibori,Y.Ishiyama, K.Tanabe, T.Ono, A.R.Ruslinda, T.asahara, J.Mizuno, A.Hiraiwa, S.Shoji, H.Kawarada
Organizer
22nd European conference on Diamond
Place of Presentation
Garmisch-Partenkirchen, Germany
Year and Date
20110900
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