2013 Fiscal Year Final Research Report
Endocrine interaction of brain and gut that governs seawater adaptation in fishes
| Project/Area Number |
23247010
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAKEI Yoshio 東京大学, 大気海洋研究所, 教授 (10129249)
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| Co-Investigator(Kenkyū-buntansha) |
KUSAKABE Makoto 東京大学, 大気海洋研究所, 助教 (40451893)
MUKUDA Takao 鳥取大学, 医学部, 講師(現職) (60346335)
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| Co-Investigator(Renkei-kenkyūsha) |
NOBATA Shigenori 東京大学, 大気海洋研究所, 特任研究員 (00522690)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 浸透圧調節 / 海水適応 / 飲水行動 / 腸による吸収 / 比較内分泌 / 水・電解質代謝 / ウナギ |
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| Research Abstract |
Marine teleosts drink copiously and absorb 90% of ingested seawater by the intestine to cope with osmotic dehydration. Thus, drinking and subsequent absorption of water by the intestine is essential to survive in hyperosmotic marine environment. The transcriptome analyses showed that the brain (regulatory site for drinking) and the gut (regulatory site for absorption) express several hormone genes and their expression is upregulated after transfer of eels to seawater. Furthermore, the brain and the gut interact with each other by regulating drinking and intestinal absorption through blood stream or via innervated nerves. We are currently performing tissue-specific knockdown of such important genes in medaka to evaluate their roles in seawater adaptation. This is the first study that demonstrate interactions between brain and gut via hormones for seawater adaptation.
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[Journal Article] Changes in plasma hormone and electrolyte concentrations after exposure to dry and SW environment in the crab-eating frog2014
Author(s)
Uchiyama, M., Maejima, S., Wong, M. K. S., Preyavichyapugdee, N., Wanich, C., Hyodo, S., Takei, Y., and Matsuda, K.
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Journal Title
Gen. Comp. Endocirnol.
Volume: 195
Pages: 40-46
Peer Reviewed
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[Journal Article] Osmotic stress transcription factor 1b (Ostf1b) promotes migration properties with the modulation of Epithelial Mesenchymal Transition (EMT) phenotype in human embryonic kidney cell2013
Author(s)
Lai, K. P., Law, A., Lau, M. C. C., Takei, Y., Tse, W. K. F., and Wong, C. K. C.
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Journal Title
Int. J. Biochem. Cell. Biol.
Volume: 45
Pages: 1921-1926
Peer Reviewed
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[Journal Article] A candidate of organum vasculosum of the lamina terminalis in eels with special reference to body fluid homeostasis2013
Author(s)
Mukuda, T, Hamasaki, S., Koyama, Y., Takei, Y., Kaidoh, T., and Inoue, T.
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Journal Title
Cell Tiss. Res.
Volume: 353
Pages: 525-538
Peer Reviewed
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[Journal Article] Establishment and validation of an aquarium system to evaluate salinity preference in conscious rainbow trout2013
Author(s)
Takei, Y., Miyanishi, H., Nobata, S., Wong, M. K. S., Watanabe, T., Ventura, A., Shiozawa, A., Hyodo, S., and Kusakabe, M.
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Journal Title
Coast. Mar. Sci.
Volume: 36
Pages: 26-34
Peer Reviewed
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[Journal Article] Shared and separate functions of the RAMP-based adrenomedullin receptors2011
Author(s)
Kuwasako, K., Kitamura, K., Nagata, S., Hikosaka, T., Takei, Y., and Kato, J.
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Journal Title
Peptides
Volume: 32
Pages: 1540-1550
Peer Reviewed
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