2014 Fiscal Year Final Research Report
Molecular physiological study on functional diversity of non-visual rhodopsins by using isolated cells
| Project/Area Number |
23247011
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Animal physiology/Animal behavior
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| Research Institution | Osaka City University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
KOYANAGI Mitsumasa 大阪市立大学, 大学院理学研究科, 准教授 (30379276)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Keywords | ロドプシン類 / 視物質 / 非視覚 |
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| Outline of Final Research Achievements |
Functional properties of diverse rhodopsins were investigated. We found that melanopsins in the zebrafish and lamprey horizontal cells had an ability to elevate intracellular calcium concentration upon light absorption. We also found that melanopsin-expressing horizontal cells connected to visual cells containing rhodopsin, which is basically involved in twilight vision, in the lamprey. In the jumping spider, absorption characteristics of a visual pigment, which is phylogenetically close to melanopsins, contributes to depth perception. In addition, homologs of vertebrate encephalopsins had an ability to decrease intracellular cAMP level via Gi type G protein activation.
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| Free Research Field |
動物生理・行動
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