2013 Fiscal Year Final Research Report
Origin of autophagic membrane: study on organelle biogenesis
| Project/Area Number |
23247034
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Cell biology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | たんぱく質分解 / オートファゴソーム / ミトコンドリア / 小胞体 / 発がん / 神経変性疾患 / 感染症 / オルガネラ |
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| Research Abstract |
Autophagy is an intracellular degradation system having multiple functions from development and differentiation to suppression of tumorigenesis, neurodegeneration, infectious diseases, etc. The membrane-bound compartment, atuophagosome executes autophagy. Where autophagosome is formed has been a target of the long-standing debate. In this project we demonstrated that is is formed the contact sites between mitochondria and the endoplasmic reticulum. Our finding resolved the enigma and provided useful information for developing autophagy regulating therapy.
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[Journal Article] Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin2013
Author(s)
Fujita N, Morita E, Itoh T, Tanaka A, Nakaoka M, Osada Y, Umemoto T, Saitoh T, Nakatogawa H, Kobayashi S, Haraguchi T, Guan JL, Iwai K, Tokunaga F, Saito K, Ishibashi K, Akira S, Fukuda M, Noda T, Yoshimori T
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Journal Title
J Cell Biol.
Volume: 203
Pages: 115-28
DOI
Peer Reviewed
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[Journal Article] Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy2013
Author(s)
Ichimura Y, Waguri S, Sou YS, Kageyama S, Hasegawa J, Ishimura R, Saito T, Yang Y, Kouno T, Fukutomi T, Hoshii T, Hirao A, Takagi K, Mizushima T, Motohashi H, Lee MS, Yoshimori T, Tanaka K, Yamamoto M, Komatsu M
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Journal Title
Mol Cell.
Volume: 51
Pages: 618-31
DOI
Peer Reviewed
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[Journal Article] Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury2013
Author(s)
Maejima I, Takahashi A, Omori H, Kimura T, Takabatake Y, Saitoh T, Yamamoto A, Hamasaki M, Noda T, Isaka Y, Yoshimori T
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Journal Title
EMBO J.
Volume: 32
Pages: 2336-47
DOI
Peer Reviewed
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[Journal Article] Autophagosomes form at ER.mitochondria contact sites2013
Author(s)
Hamasaki M, Furuta N, Matsuda A, Nezu A, Yamamoto A, Fujita N, Oomori H, Noda T, Haraguchi T, Hiraoka Y, Amano A, Yoshimori T
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Journal Title
Nature
Volume: 495
Pages: 389-93
DOI
Peer Reviewed
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[Journal Article] Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma2012
Author(s)
Shimizu S, Takehara T, Hikita H, Kodama T, Tsunematsu H, Miyagi T, Hosui A, Ishida H, Tatsumi T, Kanto T, Hiramatsu N, Fujita N, Yoshimori T, Hayashi N
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Journal Title
Int J Cancer.
Volume: 131
Pages: 548-57
DOI
Peer Reviewed
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[Journal Article] Vacuolating Cytotoxin and Variants in Atg16L1 That Disrupt Autophagy Promote Helicobacter pylori Infection in Humans2012
Author(s)
Raju D, Hussey S, Ang M, Terebiznik MR, Sibony M, Galindo-Mata E, Gupta V, Blanke SR, Delgado A, Romero-Gallo J, Ramjeet MS, Mascarenhas H, Peek RM, Correa P, Streutker C, Hold G, Kunstmann E, Yoshimori T, Silverberg MS, Girardin SE, Philpott DJ, El Omar E, Jones NL
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Journal Title
Gastroenterology.
Volume: 142
Pages: 1160-71
DOI
Peer Reviewed
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[Journal Article] Autophagy guards against Cisplatin-induced acute kidney injury2012
Author(s)
Takahashi A, Kimura T, Takabatake Y, Namba T, Kaimori J, Kitamura H, Matsui I, Niimura F, Matsusaka T, Fujita N, Yoshimori T, Isaka Y, Rakugi H
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Journal Title
Am J Pathol.
Volume: 180
Pages: 517-25
DOI
Peer Reviewed
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