Studies on the functional amino acid nutrition and ist application

2013 Fiscal Year Final Research Report

• Project/Area Number: 23248046
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Zootechnical science/Grassland science
• Research Institution: Kyushu University
• Principal Investigator: FURUSE Mitsuhiro 九州大学, (連合)農学研究科(研究院), 教授 (30209176)
• Co-Investigator(Kenkyū-buntansha): TOMONAGA Shozo 九州大学, 大学院農学研究院, 助教 (00552324) ; YASUO Shinobu 九州大学, 大学院農学研究院, 准教授 (30574719)
• Co-Investigator(Renkei-kenkyūsha): YASUO Shinobu 九州大学, 大学院農学研究院, 准教授 (30574719)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Keywords: ストレス / トリプトファン / アスパラギン酸 / セリン / チロシン / 不安様行動 / 受容体 / 睡眠

Research Abstract

Kynurenic acid (KYNA), L-tryptophan metabolite, induced a strong sedative effect under stress via the simultaneous inhibition of the alpha 7 nicotinic acetylcholine (alpha 7nACh) receptor and N-methyl-D-aspartate (NMDA) receptor subgroup containing the subunits NR2A and NR2B. L-Aspartate (L-Asp) and D-aspartate (D-Asp) also attenuates stress responses. L-Asp could induce sedative and hypnotic effects for stress behaviors through the NMDA receptor, but D-Asp might be via simultaneous involvement of other receptors besides the NMDA receptor.
Both acute and chronic L-serine treatments differently influenced an index of an antidepressant-like state. Acute L-serine increased L-serine and chronic L-serine treatment increased D-serine in the brain. The conversion of L-tyrosine to D-tyrosine in the brain of hyperactive animals may be higher, which may cause low dopamine concentration. Furthermore, L-serine, which is known as sedative factors, was lower in hyperactive animals.

Research Products

• [Journal Article] The metabolism of amino acids differs between the brains of the Djungarian hamster (P. sungorus) and the Roborovskii hamster (P. roborovskii) (2014)
  • Author(s): Ikeda, H., Kawase, T., Nagasawa, M., Chowdhury, V. S., Yasuo, S. and Furuse, M.
  • Journal Title: Springer Plus Volume: (in press)
  • Peer Reviewed
• [Journal Article] Oral administration of D-aspartate, but not L-aspartate, depresses rectal temperature and alters plasma metabolites in chicks (2014)
  • Author(s): Erwan, E., Chowdhury, V.S., Nagasawa, M., Goda, R., Otsuka, T., Yasuo, S. and Furuse, M.
  • Journal Title: Life Sciences Volume: (in press)
  • Peer Reviewed
• [Journal Article] Central injection of L-and D-aspartate attenuates isolation induced stress behavior in chicks possibly through different mechanisms (2014)
  • Author(s): Erwan, E., Chowdhury, V.S., Nagasawa, M., Goda, R., Otsuka, T., Yasuo, S. and Furuse, M.
  • Journal Title: European Journal of Pharmacology Volume: 736(C) Pages: 138-142
  • DOI: 10.1016/j.ejphar.2014.04.042
  • Peer Reviewed
• [Journal Article] Lauroyl-L-aspartate decreased food intake and body temperature in neonatal chicks (2013)
  • Author(s): Erwan, E., Chowdhury, V. S., Ito, K. and Furuse, M.
  • Journal Title: Pharmacology Biochemistry and Behavior Volume: 113( C) Pages: 7-11
  • DOI: 10.1016/j.pbb.2013.10.010
  • Peer Reviewed
• [Journal Article] Two receptors are involved in the central functions of kynurenic acid under an acute stress in neonatal chicks (2013)
  • Author(s): Yoshida, J., Shigemura, A., Ogino, Y., Denbow, D.M. and Furuse, M.
  • Journal Title: Neuroscience Volume: 248(1) Pages: 194-200
  • DOI: 10.1016/j.neuroscience.2013.06.005
  • Peer Reviewed
• [Journal Article] Hypothesis with abnormal amino acid metabolism in depression and stress vulnerability in Wistar Kyoto rats (2012)
  • Author(s): Nagasawa, M., Ogino, Y., Kurata, K., Otsuka, T., Yoshida, J., Tomonaga, S. and Furuse, M.
  • Journal Title: Amino Acids Volume: 43(5) Pages: 2101-2111
  • DOI: 10.1007/s00726-012-1294-y
  • Peer Reviewed
• [Journal Article] Central administration of L-and D-aspartate attenuates stress behaviors by social isolation and CRF in neonatal chicks (2012)
  • Author(s): Erwan, E., Tomonaga, S., Yoshida, J., Nagasawa, M., Ogino, Y., Denbow, D.M. and Furuse, M.
  • Journal Title: Amino Acids Volume: 43(5) Pages: 1969-1976
  • DOI: 10.1007/s00726-012-1272-4
  • Peer Reviewed
• [Journal Article] Intracerebroventricular injection of kynurenic acid attenuates corticotrophinreleasing hormone-augmented stress responses in neonatal chicks (2012)
  • Author(s): Yoshida, J., Tomonaga, S., Ogino, Y., Nagasawa, M., Kurata, K. and Furuse, M.
  • Journal Title: Neuroscience Volume: 220(1) Pages: 142-148
  • DOI: 10.1016/j.neuroscience.2012.06.041
  • Peer Reviewed
• [Presentation] L-およびD-アスパラギン酸の中枢投与は異なる機構を介して単離ストレス下のヒナのストレス行動を緩和する (2014)
  • Author(s): エディエルワン ,スルチョードリビシュワジット ,長澤麻央 ,五田亮世 ,大塚剛司 ,安尾しのぶ ,古瀬充宏
  • Organizer: 日本家禽学会春季大会
  • Place of Presentation: 筑波大学
  • Year and Date: 2014-03-29
• [Presentation] Wistar Kyotoラットの脳における L-セリン代謝酵素の遺伝子発現解析 (2013)
  • Author(s): 長澤麻央 ,川瀬貴博 ,池田裕美 ,岩本綾香,安尾しのぶ ,古瀬充宏
  • Organizer: 日本アミノ酸学会
  • Place of Presentation: 熊本大学
  • Year and Date: 2013-11-02
• [Presentation] ジャンガリアンハムスターとロボロフスキーハムスターにおける L-および D-アミノ酸含量の比較に関する研究 (2013)
  • Author(s): 池田裕美 ,川瀬貴博 ,長澤麻央 ,スルチョードリビシュワジット ,安尾しのぶ ,古瀬充宏
  • Organizer: 日本畜産学会第117回大会
  • Place of Presentation: 新潟大学
  • Year and Date: 2013-09-09
• [Presentation] L-セリンの単回および長期給与は Wistar KyotoラットならびにWistarラットにおいて抗うつ様効果を誘導する (2012)
  • Author(s): 長澤麻央・大塚剛司・都合勇希・山長聖和・吉田惇紀・山崎いづみ・魚津伸夫・寺本祐之・安尾しのぶ・古瀬充宏
  • Organizer: 日本アミノ酸学会
  • Place of Presentation: 千葉大学
  • Year and Date: 2012-09-28
• [Presentation] トリプトファン代謝産物の脳室投与が単離ストレス下のニワトリヒナの行動に及ぼす影響 (2012)
  • Author(s): 吉田惇紀・友永省三・荻野ユミ・重村麻子・長澤麻央・古瀬充宏
  • Organizer: 日本畜産学会第115回大会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2012-03-28
• [Presentation] 脳内キヌレン酸が単離ストレス下のニワトリヒナの行動に及ぼす影響 (2011)
  • Author(s): 吉田惇紀・友永省三・荻野ユミ・長澤麻央・倉田幸治・古瀬充宏
  • Organizer: 日本アミノ酸学会
  • Place of Presentation: 名古屋大学
  • Year and Date: 2011-11-04
• [Book] Metabolism and physiology of glutamate in chickens. In: Glutamic Acid: Chemistry, Food Sources and Health Benefits (2013)
  • Author(s): Chowdhury, V.S. and Furuse, M.(Edited by Balcazar, D.M.J. and Perez, E.A.R.)
  • Total Pages: 43-62
  • Publisher: NOVA Science Publishers Inc., Hauppauge NY, USA
• [Book] Functions of brain L-aspartate and its derivatives on stress responses. In: Tyrosine and Aspartic Acid: Properties, Sources and Health Benefits (2012)
  • Author(s): Tomonaga, S., Erwan, E., Denbow, D.M. and Furuse, M.(Edited by Jones, J.E. and Morano, D.M.)
  • Total Pages: 163-175
  • Publisher: NOVA Science Publishers Inc., Hauppauge NY, USA
• [Remarks]
  • URL: http://www.agr.kyushu-u.ac.jp/lab/lrmb/