2013 Fiscal Year Final Research Report
Understanding of host-pathogen interaction by using silkworm infection model
| Project/Area Number |
23249009
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Environmental pharmacy
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
KAITO Chikara 東京大学, 大学院薬学系研究科, 准教授 (60420238)
MATSUMOTO Yasuhiko 東京大学, 大学院薬学系研究科, 助教 (60508141)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | RNAの分解 |
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| Research Abstract |
This study revealed that a novel virulence factor of Staphylococcus aureus regulates RNA degradation. The virulence factor modified RNA and made RNA insensitive to degradation by RNase. This finding indicates a novel regulatory mechanism of RNA degradation.
This study also revealed that a hemolymph protein of silkworm inhibits virulence of S. aureus. The hemolymph protein bound S. aureus surfaces and inhibited expression of virulence genes. This finding indicates a novel defense system of host animal against pathogenic bacteria as well as a novel recognition system of S. aureus against host environment.
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[Journal Article] Mobile genetic element SCCmec-encoded psm-mec RNA suppresses translation of agrA and attenuates MRSA virulence2013
Author(s)
Kaito C, Saito Y, Ikuo M, Omae Y, Mao H, Nagano G, Fujiyuki T, Numata S, Han X, Obata K, Hasegawa S, Yamaguchi H, Inokuchi K, Ito T, Hiramatsu K, Sekimizu K
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Journal Title
PLoS Pathog.
Volume: 9
Pages: e1003269
DOI
Peer Reviewed
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[Journal Article] Transcription and translation products of the cytolysin gene psm-mec on the mobile genetic element SCCmec regulate Staphylococcus aureus virulence2011
Author(s)
Kaito C., Saito, Y., Nagano, G., Ikuo, M., Omae, Y., Hanada, Y., Han, X., Kuwahara-Arai, K., Hishinuma, T., Baba, T., Ito, T., Hiramatsu, K., and Sekimizu K
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Journal Title
PLoS Pathog
Volume: 7
Pages: e1001267
DOI
Peer Reviewed
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[Journal Article] Impact of psm-mec in the mobile genetic element on the clinical characteristics and outcome of SCCmec-II methicillin-resistant Staphylococcus aureus bacteraemia in Japan
Author(s)
Aoyagi T, Kaito C, Sekimizu K, Omae Y, Saito Y, Mao H, Inomata S, Hatta M, Endo S, Kanamori H, Gu Y, Tokuda K, Yano H, Kitagawa M, Kaku M
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Journal Title
Clin Microbiol Infect
Volume: (in press)
DOI
Peer Reviewed
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[Presentation] 新規機能性RNA psm-mecは agrA遺伝子の翻訳を抑制してメチシリン耐性黄色ブドウ球菌の病原性を抑制する2013
Author(s)
幾尾真理子, 齋藤裕樹, 大前陽輔, 毛瀚, 長野源太郎, 藤幸知子, 沼田俊介, 韓笑, 小幡佳津明, 長谷川節雄, 山口博樹, 猪口孝一, 伊藤輝代, 平松啓一, 伊藤孝司, 関水和久, 垣内力
Organizer
第86回日本生化学会大会
Place of Presentation
神奈川(横浜)
Year and Date
20130911-13
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