2015 Fiscal Year Final Research Report
Comprehensive analysis of novel monitoring markers of anticoagulation and antiplatelet therapies
| Project/Area Number |
23249030
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory medicine
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| Research Institution | Keio University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
SUZUKI Norihiro 慶應義塾大学, 医学部, 教授 (10158975)
KAWAMURA Akio 慶應義塾大学, 医学部, 講師 (60286458)
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Keywords | 血栓症 / 抗血小板薬 / 抗凝固薬 / モニタリング |
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| Outline of Final Research Achievements |
Antiplatelet drugs are used for the treatment and secondary prevention of atherothrombosis, while anticoagulant drugs are indicated for deep vein thrombosis, pulmonary thromboembolism, and atrial fibrillation. This study aimed for comprehensive exploration and development of new diagnostic markers specific for antithrombotic therapies.
For antiplatelet therapy, cerebrovascular disease, coronary artery disease, and thrombosis prevention in perioperative phases (including patch closure of ASD using clopidogrel) were investigated. PFA-100, VerfyNow, and T-TAS were shown to be effective.
For anticoagulation therapy, novel diagnostic strategies for new oral anticoagulants (NOACs) were examined. Coagulation studies vary significantly between reagents, which should always be taken into consideration when results were interpreted.
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| Free Research Field |
医歯薬学
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