2013 Fiscal Year Final Research Report

Elucidation of molecular basis and therapeutic strategy of immune-mediated neurological diseases based on comprehensive analysis of autoantibodies

Research Project

Project/Area Number	23249048
Research Category	Grant-in-Aid for Scientific Research (A)
Allocation Type	Single-year Grants
Section	一般
Research Field	Neurology
Research Institution	The University of Tokyo
Principal Investigator	TSUJI Shoji 東京大学, 医学部附属病院, 教授 (70150612)
Co-Investigator(Kenkyū-buntansha)	GOSHIMA Naoki 産業技術総合研究所, 主任研究員 (70215482) KUSUNOKI Susumu 近畿大学, 医学部, 教授 (90195438) TANAKA Keiko 金沢医科大学, 医学部, 教授 (30217020)
Co-Investigator(Renkei-kenkyūsha)	SHIMIZU Jun 東京大学, 医学部附属病院, 講師 (40260492)
Project Period (FY)	2011-04-01 – 2014-03-31
Keywords	神経病態免疫学 / プロテインアレイ
Research Abstract	Employing active protein arrays containing recombinant proteins with preserved native structures, sera from 20 patients with paraneoplastic cerebellar degeneration, immune-mediated encephalitis, acute autonomic neuronopathy, and immune-mediated myosisit are subjected to comprehensive antigen screening. Forty to 60 antigens were recognized by the individual serum. Search for homologous regions among the antigens recognized by the same serum revealed that the eiptopes are not shared among these antigens.