2013 Fiscal Year Final Research Report
Nicher Regulation for Normal Hemopoietic Stem Cells and Leukemic Stem Cells
| Project/Area Number |
23249053
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Keio University |
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Principal Investigator |
SUDA Toshio 慶應義塾大学, 医学部, 教授 (60118453)
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| Co-Investigator(Kenkyū-buntansha) |
TAKUBO Keiyo 慶應義塾大学, 医学部, 専任講師 (50502788)
NAGAMATSU Go 慶應義塾大学, 医学部, 助教 (70453545)
HOSOKAWA Kentaro 慶應義塾大学, 医学部, 特任助教 (90569584)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 造血幹細胞 / 白血病幹細胞 / ニッチ / 活性酸素 / 低酸素 |
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| Research Abstract |
Stem cell maintenance in a haltered cell-cycle state (i.e., quiescence) has been proposed as a fundamental property of HSCs. Maintenance of quiescence protects HSCs from functional exhaustion and naturally producing extrinsic cellular insults to enable lifelong hematopoietic cell production. HSC quiescence is regulated through a complex network of cell intrinsic regulations along with extrinsic influences from the microenvironment. Normal HSCs maintain intracellular hypoxia, stabilize the hypoxia-inducible factor-alpha(HIF-1a) protein and generate ATP by anaerobic metabolism. In HIF-1a-deficiency, HSCs became metabolically aerobic, lost cell cycle quiescence, and finally exhausted.
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