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2013 Fiscal Year Final Research Report

Analysis of Muscle and Tendon Development and its application to Medicine

Research Project

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Project/Area Number 23249071
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Orthopaedic surgery
Research InstitutionTokyo Medical and Dental University

Principal Investigator

ASAHARA Hiroshi  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (70294460)

Co-Investigator(Kenkyū-buntansha) TAKADA Syuji  国立成育医療研究センター, システム発生・再生医学研究部, 部長 (20382856)
Project Period (FY) 2011-04-01 – 2014-03-31
Keywords筋 / 腱 / Mkx / RP58
Research Abstract

The research focused on the formation of muscle-tendon structure complex, which is essential for motor function. RP58, a transcription factor required in the development of muscle and Mkx, essential in normal growth of tendons and ligaments were investigated. In order for to determine the mechanism for Mkx expression, promoter/enhancer region of Mkx was localized and 3 candidate transcription factors were identified. Mkx regulated genes were also investigated and identified. RP58 is known to bind to DNMT3, a de novo DNA methyltransferase, and hence DNA methylation was analyzed genome-wide and regions of methylation activity were identified.

  • Research Products

    (8 results)

All 2014 2013 2012

All Journal Article (8 results)

  • [Journal Article] FOXL2 transcriptionally represses Sf1 expression by antagonizing WT1 during ovarian development in mice2014

    • Author(s)
      Takasawa K, Kashimada K, Pelosi E, Takagi M, Morio T, Asahara H, Schlessinger D, Mizutani S, Koopman P
    • Journal Title

      The FASEB Journal

      Volume: 28 (5) Pages: 2020-28

    • DOI

      10.1096/fj.13-246108

  • [Journal Article] The Mohawk homeobox transcription factor regulates the differentiation of tendons and volar plates2014

    • Author(s)
      Onizuka N, Ito Y, Inagawa M, Nakahara H, Takada S, Lotz M, Toyama Y, Asahara H
    • Journal Title

      J Orthop Sci

      Volume: 19(1) Pages: 172-80

    • DOI

      10.1007/s00776-013-0485-z

  • [Journal Article] Targeted gene deletion of miRNAs in mice by TALEN system2013

    • Author(s)
      Takada S, Sato T, Ito Y, Yamashita S, Kato T, Kawasumi M, Kanai-Azuma M, Igarashi A, Kato T, Tamano M, Asahara H
    • Journal Title

      PLOS One

      Volume: 8(10) Pages: e76004

    • DOI

      10.1371/journal.pone.0076004

  • [Journal Article] The AERO System : a 3D-like Approach for Recording Gene Expression Patterns in the Whole Mouse Embryo2013

    • Author(s)
      Shimizu H, Kubo A, Uchibe K, Hashimoto M, Yokoyama S, Takada S, Mitsuoka K, Asahara H
    • Journal Title

      PLOS One

      Volume: 8(10) Pages: e75754

    • DOI

      10.1371/journal.pone.0075754

  • [Journal Article] Transcription factor mohawk and the pathogenesis of human anterior cruciate ligament degradation2013

    • Author(s)
      Nakahara H, Hasegawa A, Otabe K, Ayabe F, Matsukawa T, Onizuka N, Ito Y, Ozaki T, Lotz MK, Asahara H
    • Journal Title

      Arthritis Rheum

      Volume: 65(8) Pages: 2081-9

    • DOI

      10.1002/art.38020

  • [Journal Article] MAML1 enhances the transcriptional activity of Runx2 and plays a role in bone development2013

    • Author(s)
      Watanabe T, Oyama T, Asada M, Harada D, Ito Y, InagawaM, Suzuki Y, Sugano S, Katsube K, Karsenty G, Komori T, Kitagawa M, Asahara H
    • Journal Title

      PLOS Genetics

      Volume: 9(1) Pages: e1003132

    • DOI

      10.1371/journal.pgen.1003132

  • [Journal Article] Identification of novel transcription-regulating genes expressed during murine molar development2013

    • Author(s)
      Uchibe K, Shimizu H, Yokoyama S, Kuboki T, Asahara H
    • Journal Title

      DevDyn

      Volume: 241(7) Pages: 1217-26

    • DOI

      10.1002/dvdy.23808

  • [Journal Article] Analysis of microRNAs expressions in chondrosarcoma2012

    • Author(s)
      Yoshitaka T, Kawai A, Miyaki S, Numoto K, Kikuta K, Ozaki T, Lotz M, Asahara H
    • Journal Title

      J Orthop Res

      Volume: 31(12) Pages: 1992-8

    • DOI

      10.1002/jor.22457

URL: 

Published: 2015-06-25   Modified: 2019-12-16  

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