2013 Fiscal Year Final Research Report
Development of a molecular-targeting therapeutic agent for cancer therapy using a cancer-targeting liposome coupled with viral proteins
| Project/Area Number |
23249084
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Surgical dentistry
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| Research Institution | Chiba University |
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Principal Investigator |
TANZAWA HIDEKI 千葉大学, 医学(系)研究科(研究院), 教授 (50236775)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRASAWA Hiroshi 千葉大学, 大学院・医学研究院, 教授 (00216194)
SAITO Kengo 千葉大学, 大学院・医学研究院, 助教 (70451755)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 臨床腫瘍学 |
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| Research Abstract |
We developed a new strategy of chemotherapy and/or radiation therapy against treatment-resistant tumor using with the cancer-targeting liposome loading the some sensitizer. In this therapy, these liposomes exhibited higher cytotoxicity to cancer cells than the only sensitizer and displayed the tumor regression in mice bearing a drug or radiation resistant tumor.
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Research Products
(5 results)
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[Journal Article] Lipocalin-2 is associated with radioresistance in oral cancer and lung cancer cells2013
Author(s)
Shiiba M, Saito K, Fushimi K, Ishigami T, Shinozuka K, Nakashima D, Kouzu Y, Koike H, Kasamatsu A, Sakamoto Y, Ogawara K, Uzawa K, Takiguchi Y, Tanzawa H
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Journal Title
Int J Oncol
Volume: 42(4)
Pages: 1197-204
Peer Reviewed
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[Journal Article] Preparation and characterization of phospholipid-conjugated indocyanine green as a near-infrared probe2012
Author(s)
Suganami A, Toyota T, Okazaki S, Saito K, Miyamoto K, Akutsu Y, Kawahira H, Aoki A, Muraki Y, Madono T, Hayashi H, Matsubara H, Omatsu T, Shirasawa H, Tamura Y
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Journal Title
Bioorg Med Chem Lett
Volume: 22(24)
Pages: 7481-5
Peer Reviewed
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