Development of predictive periodontology based on molecular epidemiological study

2014 Fiscal Year Final Research Report

• Project/Area Number: 23249086
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Periodontal dentistry
• Research Institution: Osaka University
• Principal Investigator: MURAKAMI Shinya 大阪大学, 歯学研究科(研究院), 教授 (70239490)
• Co-Investigator(Kenkyū-buntansha): KITAMURA Masahiro 大阪大学, 大学院歯学研究科, 准教授 (10243247) ; YAMADA Satoru 大阪大学, 歯学部附属病院, 講師 (40359849) ; YAMASHITA Motozo 大阪大学, 歯学部附属病院, 助教 (90524984) ; KITAGAKI Jirouta 大阪大学, 歯学部附属病院, 助教 (90570292)
• Co-Investigator(Renkei-kenkyūsha): IKEBE Kazunori 大阪大学, 大学院歯学研究科, 准教授 (70273696) ; KAMIDE Kei 大阪大学, 大学院医学系研究科, 講師 (80393239) ; GONDO Yasuyuki 大阪大学, 大学院人間科学研究科, 准教授 (40250196)
• Project Period (FY): 2011-04-01 – 2015-03-31
• Keywords: 歯周病 / 侵襲性歯周炎 / 分子疫学 / 疾患関連遺伝子 / バイオインフォマティクス

Outline of Final Research Achievements

In this study, we investigated the genes responsible for progression of periodontal disease based on the information of molecular epidemiological studies of over 70-year-old adult, aged twins and aggressive periodontitis patients. Moreover, we analyzed the expression and function of the various candidate genes. As a result, we confirmed that genetic factor is associated with the progression of periodontal disease and found that cathepsin A might be a responsible gene for aggressive periodontitis as assessed by the epidemiological database. We also revealed that CD73, PLAP-1, ferritin, and periostin are deeply involved in the cytodifferentiation and mineralization of periodontal ligament cells which play crucial roles in periodontal tissue homeostasis.

Free Research Field

歯周予防学