2013 Fiscal Year Final Research Report
A study of the molecular mechanism underlying activity-dependent thalamocortical axon branching
| Project/Area Number |
23300118
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SUGO Noriyuki 大阪大学, 大学院・生命機能研究科, 助教 (20372625)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 大脳 / 神経活動 / 軸索 / 分岐 / 標的由来因子 / エンドサイトーシス |
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| Research Abstract |
During development neural circuits are established not only by molecular cues but also neuronal activity. In the present study, we attempted to reveal the molecular mechanisms that underlie activity-dependent axon branching, focusing on the thalamocortical projection. As a result, we found that netrin-4 is expressed in cortical cells in an activity-dependent fashion and promotes branch formation of thalamocortical axons. Moreover, endocytosis in presynaptic sites, which is regulated by firing activity, promotes axon branching by increasing uptake of neurotrophic factors.
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