2013 Fiscal Year Final Research Report
Molecular basis for the secondary neural circuit formation in the mouse olfactory system
| Project/Area Number |
23300140
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2011-11-18 – 2014-03-31
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| Keywords | 嗅覚 / 遺伝子改変マウス / 神経回路形成 / シナプス結合 / 再生 |
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| Research Abstract |
In the mouse olfactory system, map topography is largely established by axon-axon interactions of olfactory sensory neurons (OSNs). However, to make the map functional, the OSNs must make proper connections to the mitral/tufted (M/T) cells. Then, how do the M/T cell dendrites find their partner glomeruli for synapse formation with OSN axons? Does the odorant receptor (OR) specificity of glomeruli play an instructive role in matching M/T cell dendrites with OSN axons? To address these questions, we analyzed dendrite selection and synapse formation of mitral cells in various mutant mice in which glomerular formation was perturbed. We also studied synapse reconstitution in adult glomeruli. Our present results support the "proximity model", whereby mitral cells tend to connect primary dendrites to the nearest neighboring glomeruli regardless of OR specificity. The map location or address code of glomeruli plays a key role in matching mitral cells with their partner glomeruli.
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[Journal Article] Agonist-independent GPCR activity regulates anterior-posterior targeting of olfactory sensory neurons2013
Author(s)
Nakashima A., Takeuchi H., Imai T., Saito H., Kiyonari H., Abe T., Chen A., Weinstein L.S., Yu C.R., Storm D.R., Nishizumi H., and Sakano H
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Journal Title
Cell
Volume: 154
Pages: 1314-1325
DOI
Peer Reviewed
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