2013 Fiscal Year Final Research Report
Study for neural mechanism of wakefulness and dependence using optogenetics
| Project/Area Number |
23300142
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | Nagoya University (2012-2013)
National Institute for Physiological Sciences (2011) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
田中 謙二 慶應義塾大学, 特任准教授 (30329700)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Keywords | 覚醒 / 依存 / 遺伝子改変マウス / 光遺伝学 |
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| Research Abstract |
Orexin producing neurons are distributed in the hypothalamus. These neurons are involved in the maintenance of wakefulness. Specific loss of orexin neurons is caused by sleep disorder, Narcolepsy. Although drugs which easily form dependence are used for treatment of Narcolepsy, it is very rare to form dependence in Narcoleptic patients. These facts suggest that orexin neurons are involved in the dependence as well. In this study, we studied the role of orexin neurons in formation of dependence using optogenetics. Additionally, we evaluated the role of orexin neurons on the regulation of sleep/wakefulness and dependence.
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Research Products
(30 results)
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[Journal Article] Greatly increased numbers of histamine cells in human narcolepsy with cataplexy2013
Author(s)
John J, Thannickal TC, McGregor R, Ramanathan L, Ohtsu H, Nishino S, Sakai N,Yamanaka A, Stone C, Cornford M, Siegel JM
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Journal Title
Ann Neurol
Volume: 74(6)
Pages: 786-93
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