2014 Fiscal Year Final Research Report
Model animals by nonhuman primate for Alzheimer disease, hyper expression of mutant amyloid precursor protein and formation of senile plaques in the brain
| Project/Area Number |
23300155
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Laboratory animal science
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| Research Institution | Shiga University of Medical Science |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
OKADA Takashi 日本医科大学, 医学研究科, 教授 (00326823)
NISHIMURA Masaki 滋賀医科大学, 分子神経科学研究センター, 教授 (40322739)
MATSUO Akinori 滋賀医科大学, 分子神経科学研究センター, 助教 (20324585)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Keywords | アルツハイマー病 / アミロイドβ / アデノ随伴ウイルス / カニクイザル |
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| Outline of Final Research Achievements |
It takes more than 20 years to build up Alzheimer-related histological features in the brains of nonhuman primates. Therefore, an artificial primate model would be required to improve it. We planned that Adeno-associated virus vector recombined with a candidate gene (Sweden type APP) for onset of Alzheimer disease inoculated to 3 months old mice. As a result, the inoculated mice increased to secrete A beta 1-40 more than control mice. Since this recombined viral vector possesses an ability of hyper expression of A beta, we attempt now to inoculate the vector and are checking the effect of it using cynomolgus monkeys.
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| Free Research Field |
実験動物学
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